Expression patterns of and in colorectal cancer patients.

Circular RNAs (circRNAs) are non-coding, single-stranded RNAs considered by their closed-loop structures. Research has established a connection between circRNAs and cancer progression. The objective of this project was to evaluate the expression levels of a newly discovered circRNA, (), along with its target gene, . The study involved 60 patients diagnosed with Colorectal cancer (CRC) and 60 healthy individuals as controls. Total RNA was extracted from blood samples, converted into cDNA, and analyzed using qRT-PCR. The findings revealed an up-regulation of and a down-regulation of in the blood samples of CRC patients. An inverse relationship was observed between the levels of and ; however, there was no significant difference in circRFX3 expression levels between stages I+II and stages III+IV. The levels of miR-587 expression were linked to tumor size and location. Both and play significant roles in the pathophysiology of CRC; however, additional research is necessary to elucidate their specific contributions to CRC development.