Van Thiel D H, Gavaler J S, Zajko A B, Cobb C F
J Pediatr Gastroenterol Nutr. 1985 Aug;4(4):616-21.
Prepubertal male rats underwent bile-duct ligation or a sham operation. Sham-operated animals were divided into two groups: isocalorically-fed (matched to the bile-duct-ligated animals) and ad-libitum-fed animals. At 60 days of age (after puberty in a male rat) all animals were killed. Bile-duct-ligated animals had larger livers, greater bilirubin, greater bile acid, greater aspartate transaminase, and greater alkaline phosphatase levels and lower testosterone and luteinizing hormone levels in their serum than did the controls. Moreover, the testes and seminal vesicles were smaller in the bile-duct-ligated animals than in the controls. These data suggest that chronic cholestasis contributes, at least in part, to the pubertal and maturational failure that occurs with the chronic cholestatic diseases of childhood.
青春期前雄性大鼠接受胆管结扎或假手术。假手术动物分为两组：等热量喂养（与胆管结扎动物匹配）和自由进食动物。在60日龄（雄性大鼠青春期后）时，所有动物均被处死。与对照组相比，胆管结扎动物的肝脏更大，血清胆红素、胆汁酸、天冬氨酸转氨酶和碱性磷酸酶水平更高，而睾酮和黄体生成素水平更低。此外，胆管结扎动物的睾丸和精囊比对照组小。这些数据表明，慢性胆汁淤积至少部分导致了儿童慢性胆汁淤积性疾病所伴发的青春期发育和成熟障碍。
