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1
Direct Amoxicillin Challenges for Penicillin Allergy Through Pediatric Primary Care Group Visits: A Pilot Study.通过儿科初级保健小组问诊对青霉素过敏患者进行直接阿莫西林激发试验:一项试点研究。
Open Forum Infect Dis. 2025 Apr 24;12(5):ofaf236. doi: 10.1093/ofid/ofaf236. eCollection 2025 May.
2
Inpatient allergy delabeling of pediatric patients with low-risk penicillin allergy status through direct oral amoxicillin challenge.通过直接口服阿莫西林挑战,对低风险青霉素过敏状态的儿科住院患者进行过敏标签剔除。
Allergy Asthma Proc. 2024 Jan 1;45(1):61-69. doi: 10.2500/aap.2024.45.230069.
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Antepartum vs postpartum amoxicillin oral challenge in pregnant patients with a reported penicillin allergy: A two-center prospective cohort study.报告青霉素过敏的孕妇产前与产后阿莫西林口服激发试验:一项两中心前瞻性队列研究。
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The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis.非过敏专科医生支持青霉素过敏评估和重新标记成人和儿科患者的干预措施的效果:系统评价和荟萃分析。
Int J Infect Dis. 2023 Apr;129:152-161. doi: 10.1016/j.ijid.2022.11.026. Epub 2022 Nov 28.
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Clin Infect Dis. 2021 Aug 2;73(3):487-496. doi: 10.1093/cid/ciaa653.
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Nonallergist Delabeling-Should Penicillin Allergy Delabeling Only Be Performed by Allergists?非过敏症专科医生去除标注——青霉素过敏标注的去除是否应仅由过敏症专科医生进行?
J Allergy Clin Immunol Pract. 2025 May;13(5):1011-1017.e2. doi: 10.1016/j.jaip.2024.11.028. Epub 2024 Dec 24.
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Penicillin allergy delabeling has a significant impact on subsequent antibiotic use in primary care.青霉素过敏标签去除对基层医疗中后续抗生素使用有重大影响。
World Allergy Organ J. 2024 Aug 22;17(9):100958. doi: 10.1016/j.waojou.2024.100958. eCollection 2024 Sep.
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A new pathway for penicillin delabeling in Norway.挪威青霉素去标记的一条新途径。
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Safe Penicillin Allergy Delabeling in Primary Care: A Systematic Review and Meta-Analysis.安全去除初级保健中青霉素过敏标签:系统评价和荟萃分析。
J Allergy Clin Immunol Pract. 2024 Sep;12(9):2415-2426.e1. doi: 10.1016/j.jaip.2024.06.017. Epub 2024 Jun 18.

本文引用的文献

1
Impact of Parent-Reported Antibiotic Allergies on Pediatric Antimicrobial Stewardship Programs.家长报告的抗生素过敏对儿童抗菌药物管理计划的影响。
J Allergy Clin Immunol Pract. 2025 May;13(5):1083-1093.e12. doi: 10.1016/j.jaip.2025.01.007. Epub 2025 Jan 10.
2
Nonallergist Delabeling-Should Penicillin Allergy Delabeling Only Be Performed by Allergists?非过敏症专科医生去除标注——青霉素过敏标注的去除是否应仅由过敏症专科医生进行?
J Allergy Clin Immunol Pract. 2025 May;13(5):1011-1017.e2. doi: 10.1016/j.jaip.2024.11.028. Epub 2024 Dec 24.
3
Caregiver perceptions on pediatric penicillin allergy delabeling in a primary care setting.在初级保健机构中照顾者对儿童青霉素过敏标签去除的看法。
Ann Allergy Asthma Immunol. 2024 Sep;133(3):349-351. doi: 10.1016/j.anai.2024.06.004. Epub 2024 Jun 13.
4
Impact of Penicillin Allergy Label on Clinical Outcomes of Pneumonia in Children.青霉素过敏标签对儿童肺炎临床结局的影响。
J Allergy Clin Immunol Pract. 2023 Jun;11(6):1899-1906.e2. doi: 10.1016/j.jaip.2023.03.018. Epub 2023 Mar 21.
5
Delabeling penicillin allergy in a pediatric primary care clinic.在儿科初级保健诊所消除青霉素过敏标签
Ann Allergy Asthma Immunol. 2023 May;130(5):667-669. doi: 10.1016/j.anai.2023.01.034. Epub 2023 Feb 2.
6
The Safety of the Direct Drug Provocation Test in Beta-Lactam Hypersensitivity in Children: A Systematic Review and Meta-Analysis.儿童β-内酰胺类药物过敏的直接药物激发试验安全性:系统评价和荟萃分析。
J Allergy Clin Immunol Pract. 2023 Feb;11(2):506-518. doi: 10.1016/j.jaip.2022.11.035. Epub 2022 Dec 14.
7
Penicillin Allergy Evaluation and Health Equity: A Call to Action.青霉素过敏评估与健康公平:行动呼吁。
J Allergy Clin Immunol Pract. 2023 Feb;11(2):422-428. doi: 10.1016/j.jaip.2022.12.001. Epub 2022 Dec 12.
8
Drug allergy: A 2022 practice parameter update.药物过敏:2022年实践参数更新
J Allergy Clin Immunol. 2022 Dec;150(6):1333-1393. doi: 10.1016/j.jaci.2022.08.028. Epub 2022 Sep 17.
9
Penicillin Allergy Delabeling: A Multidisciplinary Opportunity.青霉素过敏标签修正:一个多学科的机会。
J Allergy Clin Immunol Pract. 2020 Oct;8(9):2858-2868.e16. doi: 10.1016/j.jaip.2020.04.059.
10
Partnering with general pediatricians to delabel penicillin allergies in children.与普通儿科医生合作去除儿童青霉素过敏标签。
Ann Allergy Asthma Immunol. 2020 Jul;125(1):105-107. doi: 10.1016/j.anai.2020.04.001. Epub 2020 Apr 11.

通过儿科初级保健小组问诊对青霉素过敏患者进行直接阿莫西林激发试验:一项试点研究。

Direct Amoxicillin Challenges for Penicillin Allergy Through Pediatric Primary Care Group Visits: A Pilot Study.

作者信息

Chow Timothy G, Mercadel Candice, Alvarez Kristin S, Kellam Madeline, Khan David A, Termulo Cesar

机构信息

Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Center of Innovation and Value at Parkland, Parkland Health, Dallas, Texas, USA.

出版信息

Open Forum Infect Dis. 2025 Apr 24;12(5):ofaf236. doi: 10.1093/ofid/ofaf236. eCollection 2025 May.

DOI:10.1093/ofid/ofaf236
PMID:40322269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12048795/
Abstract

Novel strategies are needed to expand equitable access to penicillin allergy testing. We performed a pilot study of penicillin allergy testing through direct challenges performed at pediatric primary care group office visits. Ninety-five percent of subjects were delabeled with no severe reactions noted, providing conceptual basis for further implementation studies.

摘要

需要新的策略来扩大青霉素过敏检测的公平可及性。我们通过在儿科初级保健组办公室就诊时进行直接激发试验,开展了一项青霉素过敏检测的试点研究。95%的受试者被去除过敏标签,未观察到严重反应,为进一步的实施研究提供了概念基础。