Dung Nguyen Tien, Tram Hoang Thi Ngoc, Hang Vu Thi Thu, Thuy Pham Thi
Department of Internal Medicine, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam.
Department of Obstetrics and Gynecology, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam.
Med Arch. 2025;79(1):52-55. doi: 10.5455/medarh.2025.79.52-55.
Diabetic nephropathy is one of the causes of chronic kidney disease with a very complex mechanism, in which oxidative stress plays an important role and bilirubin acts as an effective antioxidant, protecting cells from damage caused by oxidative stress.
The aim of the study was to investigate the relationship between plasma bilirubin concentration with glomerular filtration rate and creatinine in patients with type 2 diabetes with renal damage.
Total amount of 60 patients with type 2 diabetes with renal damage. Study design was descriptive.
Mean age 64.1±4.76. The rate of decreased glomerular filtration rate was 86.7% and increased albuminuria accounted for 96.7%. The concentration of total bilirubin in plasma decreased correspondingly to the decrease in glomerular filtration rate. The concentration of total, free and conjugated bilirubin was negatively correlated with creatinine concentration (r=-0.48), (r=-0.37), (r=-0.34) and positively correlated with glomerular filtration rate (r=0.54), (r=0.45), (r=0.41) with p<0.05). The area under the curve (AUC) of total bilirubin concentration was 0.7, lower than the area under the curve (AUC) of creatinine concentration 0.8, uric acid 0.74.
Plasma bilirubin concentration is inversely correlated with creatinine concentration and positively correlated with glomerular filtration rate.
糖尿病肾病是慢性肾脏病的病因之一，其机制非常复杂，氧化应激在其中起重要作用，而胆红素作为一种有效的抗氧化剂，可保护细胞免受氧化应激造成的损伤。
本研究旨在探讨2型糖尿病肾损害患者血浆胆红素浓度与肾小球滤过率及肌酐之间的关系。
选取60例2型糖尿病肾损害患者。研究设计为描述性研究。
平均年龄64.1±4.76岁。肾小球滤过率下降率为86.7%，蛋白尿增加者占96.7%。血浆总胆红素浓度随肾小球滤过率的降低而相应下降。总胆红素、游离胆红素和结合胆红素浓度与肌酐浓度呈负相关（r=-0.48），（r=-0.37），（r=-0.34），与肾小球滤过率呈正相关（r=0.54），（r=0.45），（r=0.41），p<0.05。总胆红素浓度的曲线下面积（AUC）为0.7，低于肌酐浓度的曲线下面积（AUC）0.8、尿酸的曲线下面积（AUC）0.74。
血浆胆红素浓度与肌酐浓度呈负相关，与肾小球滤过率呈正相关。
