Redalieu E, Chan K K, Tipnis V, Zak S B, Gilleran T G, Wagner W E, LeSher A R
J Pharm Sci. 1985 Jul;74(7):765-7. doi: 10.1002/jps.2600740714.
The kinetics of absorption of hydrochlorothiazide was studied in four adult male volunteers. Plasma levels were monitored for 48 h after a 100-mg dose. Food, electrolyte, and water intake were regulated as far as possible. The plasma level data were fitted to a two-compartment open model with either first-order or zero-order absorption, using the pharmacokinetic computer program AUTOAN. A better fit of the data, both graphically and statistically, was obtained with zero-order absorption kinetics. Additional confirmation of absorption kinetics was obtained by treating the plasma level results by the Loo-Riegelman method. Cartesian graphs of the amount absorbed verus time afforded linear plots, which indicate a zero-order process.
在四名成年男性志愿者中研究了氢氯噻嗪的吸收动力学。给予100毫克剂量后，监测血浆水平48小时。尽可能控制食物、电解质和水的摄入量。使用药代动力学计算机程序AUTOAN，将血浆水平数据拟合为具有一级或零级吸收的二室开放模型。零级吸收动力学在图形和统计学上都能更好地拟合数据。通过Loo-Riegelman方法处理血浆水平结果，获得了吸收动力学的额外证实。吸收量与时间的直角坐标图呈现线性关系，表明这是一个零级过程。
