Wang Hongli, Wang Tengyue, He Zhixing, Wen Chengping, Huang Lin, Wang Mingzhu
Research Institute of Chinese Medical Clinical Foundation and Immunology, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
J Inflamm Res. 2025 Apr 28;18:5741-5757. doi: 10.2147/JIR.S512652. eCollection 2025.
Type 3 Innate lymphoid cells (ILC3s) play a crucial role in intestinal immune function by serving as an innate effector that contributes to early-life defense against pathogens and helps protect the intestines from bacterial infections. ILC3s exert their immune function through cytokine secretion, patrolling actions and the generation of memory ILC3s that aid in repairing epithelial tissue and preserving mucosal barrier integrity. Moreover, dysregulation of ILC3s function has been implicated in the pathogenesis and progression of autoimmune diseases. This comprehensive review aims to explore the interactions between gut microbes, gut microbial metabolites, and diet in relation to ILC3s within the context of the gut microenvironment. Furthermore, the gut microenvironment has the potential to influence distant extra-intestinal sites through immunomodulation, thereby modifying their risk of inflammation. The gut has emerged as a significant focus of autoimmune disease research in recent years. However, the relationship between gut ILC3s and autoimmune diseases remains poorly understood. This paper aims to examine the potential association between ILC3s and autoimmune diseases.
3型固有淋巴细胞（ILC3s）作为一种固有效应细胞，在肠道免疫功能中发挥着关键作用，有助于早期抵御病原体，并帮助保护肠道免受细菌感染。ILC3s通过分泌细胞因子、进行巡逻活动以及产生有助于修复上皮组织和维持黏膜屏障完整性的记忆性ILC3s来发挥其免疫功能。此外，ILC3s功能失调与自身免疫性疾病的发病机制和进展有关。这篇综述旨在探讨肠道微生物、肠道微生物代谢产物和饮食在肠道微环境背景下与ILC3s之间的相互作用。此外，肠道微环境有可能通过免疫调节影响远处的肠外部位，从而改变其炎症风险。近年来，肠道已成为自身免疫性疾病研究的重要焦点。然而，肠道ILC3s与自身免疫性疾病之间的关系仍知之甚少。本文旨在探讨ILC3s与自身免疫性疾病之间的潜在关联。
