Rahman Vanita, Becker Roxanne, Gray Shannon, Holubkov Richard, Loomis James, Barnard Neal
Physicians Committee for Responsible Medicine, Washington, DC, USA (VR, RB, SG, JL, NB).
University of Utah School of Medicine, Salt Lake City, UT, USA (RH).
Am J Lifestyle Med. 2025 May 1:15598276251339396. doi: 10.1177/15598276251339396.
To determine the feasibility and efficacy of a plant-based nutrition intervention for type 2 diabetes in a primary care setting. Adults (n = 76) with type 2 diabetes were enrolled in a self-paid, online nutrition intervention program between August 2023 and September 2024. All participants were advised to attend weekly group classes and follow a plant-based diet for 12 weeks. Body weight, medication usage, HbA and cholesterol levels were assessed at baseline and at 12 weeks. Among the 58 participants who completed the program (mean age 63.4 years; 69% female), the mean body weight (-3.7 kg; 95% CI, -4.4 to -2.9; .0001) and HbA (-0.6%; 95% CI, -0.8 to -0.3; = .0001) decreased at 12 weeks. Participants not following a plant-based diet at baseline experienced greater reductions in mean body weight and HbA. Total and low-density lipoprotein cholesterol levels decreased amongst participants not taking lipid-lowering medications, and 22% of participants reduced the dosages of diabetes medications. In a primary care setting, a novel 12-week plant-based nutrition intervention for type 2 diabetes was accessible, economically viable, and led to reductions in diabetes medications, body weight, HbA, and total and LDL cholesterol levels.
为确定在初级保健环境中基于植物性营养的干预措施对2型糖尿病的可行性和疗效。2023年8月至2024年9月期间，76名2型糖尿病成人参加了一个自费的在线营养干预项目。所有参与者均被建议参加每周的小组课程，并遵循基于植物性的饮食12周。在基线和12周时评估体重、药物使用情况、糖化血红蛋白（HbA）和胆固醇水平。在完成该项目的58名参与者（平均年龄63.4岁；69%为女性）中，12周时平均体重（-3.7 kg；95%置信区间，-4.4至-2.9；P<0.0001）和糖化血红蛋白（-0.6%；95%置信区间，-0.8至-0.3；P = 0.0001）下降。基线时未遵循基于植物性饮食的参与者平均体重和糖化血红蛋白下降幅度更大。未服用降脂药物的参与者总胆固醇和低密度脂蛋白胆固醇水平下降，22%的参与者减少了糖尿病药物剂量。在初级保健环境中，一种针对2型糖尿病的新型12周基于植物性营养的干预措施是可行的、经济上可行的，并导致糖尿病药物、体重、糖化血红蛋白以及总胆固醇和低密度脂蛋白胆固醇水平降低。
