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床旁超声:评估类风湿关节炎中尺神经病变的可行替代方法?

Point-of-care ultrasound: a viable alternative for assessing ulnar neuropathy in rheumatoid arthritis?

作者信息

Azzam Adel, Mansy Mohamed, Ghazaly Abdel Hamid, Al-Tamimy Hegazy

机构信息

Department of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Egypt.

出版信息

J Ultrason. 2025 May 3;25(101):20250013. doi: 10.15557/jou.2025.0013. eCollection 2025 Apr.

DOI:10.15557/jou.2025.0013
PMID:40322744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049232/
Abstract

AIM OF THE STUDY

This study seeks to evaluate the effectiveness of ultrasound measurements of the ulnar nerve cross-sectional area in comparison to electrodiagnostic tests for identifying ulnar nerve entrapment at the elbow in rheumatoid arthritis.

PATIENTS AND METHODS

This study was designed as a cross-sectional observational analysis involving 90 individuals, divided into three groups: Group A consisted of 30 individuals diagnosed with rheumatoid arthritis without clinical signs of ulnar neuropathy at the elbow; Group B included 30 individuals with rheumatoid arthritis exhibiting clinical indicators of ulnar neuropathy at the elbow; and Group C comprised 30 healthy controls. Each participant underwent a thorough medical history assessment, along with both clinical and neurological evaluations. Additionally, ultrasound and electrophysiological assessments of the ulnar nerve were performed.

RESULTS

There was no significant demographic difference between the groups, except for age, which was notably lower in Group A compared to Group B. Additionally, abnormalities in nerve conduction studies and cross-sectional area were found to be significantly greater in Group B ( <0.0001). The cross-sectional area demonstrated diagnostic accuracy rates of 52.22%, 62.22%, and 78.89% for identifying ulnar neuropathy at Guyon's canal, the medial epicondyle, and based on the elbow-to-wrist ratio, respectively.

CONCLUSION

Ultrasonography exhibits high diagnostic accuracy, especially with the cross-sectional area at the medial epicondyle and the elbow-to-wrist cross-sectional area ratio serving as important indicators for ulnar nerve entrapment in patients with rheumatoid arthritis.

摘要

研究目的

本研究旨在评估超声测量尺神经横截面积与电诊断测试相比,在类风湿关节炎患者中识别肘部尺神经卡压的有效性。

患者与方法

本研究设计为横断面观察性分析,纳入90例个体,分为三组:A组由30例诊断为类风湿关节炎但无肘部尺神经病变临床体征的个体组成;B组包括30例有类风湿关节炎且表现出肘部尺神经病变临床指标的个体;C组由30例健康对照组成。每位参与者均接受了全面的病史评估以及临床和神经学评估。此外,还对尺神经进行了超声和电生理评估。

结果

除年龄外,各组之间在人口统计学上无显著差异,A组年龄明显低于B组。此外,B组神经传导研究和横截面积异常显著更高(<0.0001)。横截面积在识别Guyon管、内上髁处的尺神经病变以及基于肘腕比时,诊断准确率分别为52.22%、62.22%和78.89%。

结论

超声检查具有较高的诊断准确性,尤其是以内上髁处的横截面积和肘腕横截面积比作为类风湿关节炎患者尺神经卡压的重要指标时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/1705860ba2fb/j_jou.2025.0013_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/520d18f3e84a/j_jou.2025.0013_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/9d96c66ec551/j_jou.2025.0013_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/1705860ba2fb/j_jou.2025.0013_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/520d18f3e84a/j_jou.2025.0013_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/9d96c66ec551/j_jou.2025.0013_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3db8/12049232/1705860ba2fb/j_jou.2025.0013_fig_003.jpg

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Arch Rheumatol. 2022 Oct 21;38(2):183-188. doi: 10.46497/ArchRheumatol.2023.9027. eCollection 2023 Jun.
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Relationship between Clinical Severity and Cross-sectional Area of Ultrasonographic Examinations in Ulnar Neuropathy at the Elbow.肘部尺神经病变超声检查临床严重程度与横截面积的关系
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Challenges in the management of older patients with inflammatory rheumatic diseases.
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Immune Axonal Neuropathies Associated With Systemic Autoimmune Rheumatic Diseases.与系统性自身免疫性风湿疾病相关的免疫性轴索性神经病
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C-reactive protein and implications in rheumatoid arthritis and associated comorbidities.C反应蛋白及其在类风湿关节炎和相关合并症中的意义。
Semin Arthritis Rheum. 2021 Feb;51(1):219-229. doi: 10.1016/j.semarthrit.2020.11.005. Epub 2020 Dec 17.
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Clinical characteristics of rheumatoid arthritis patients with peripheral neuropathy and potential related risk factors.类风湿关节炎伴周围神经病变患者的临床特征及潜在相关危险因素。
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