Nalawade Digvijay D, Jadhav Ajitkumar, Wadhokar Pratik S, Khan Anishkumar, Gupta Aryan, Malani Susheel Kumar
Department of Cardiology, Dr. D Y Patil Medical College Hospital & Research Centre, Pimpri-Chinchwad, India.
Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth University, Pune, Maharashtra, India.
J Tehran Heart Cent. 2024 Apr;19(2):147-150. doi: 10.18502/jthc.v19i2.16207.
Brugada phenocopy is considered when a Brugada-type ECG pattern is present but with a low likelihood of true Brugada syndrome, as indicated by negative family history, genetic testing, or provocative testing with drugs, or ECG normalization after the removal of precipitants. Brugada phenocopy has been reported due to various causes such as fever and electrolyte imbalance. We describe a 22-year-old man who presented with aluminum phosphide poisoning, resulting in severe metabolic acidosis, myocarditis, and profound myocardial depression. He developed transient Brugada-like ECG changes and multiorgan dysfunction, requiring intensive management, including mechanical ventilation and inotropes. Brugada phenocopy is a rare manifestation of aluminum phosphide-associated toxic myocarditis. After a week of treatment, there was a significant improvement in cardiac function and overall clinical status.
当出现Brugada型心电图模式，但根据家族史阴性、基因检测或药物激发试验为阴性，或去除诱因后心电图恢复正常等情况，提示真正的Brugada综合征可能性较低时，可考虑Brugada拟表型。已有报道称Brugada拟表型可由多种原因引起，如发热和电解质失衡。我们描述了一名22岁男性，因磷化铝中毒出现严重代谢性酸中毒、心肌炎和严重心肌抑制。他出现了短暂的Brugada样心电图改变和多器官功能障碍，需要包括机械通气和使用血管活性药物在内的强化治疗。Brugada拟表型是磷化铝相关中毒性心肌炎的一种罕见表现。经过一周的治疗，心脏功能和整体临床状况有了显著改善。
