Guru Satyabrata, Kumar Rajesh, Behera Anupama, Patra Subhabrata, Kumar Prakash
Trauma and Emergency Medicine/Internal Medicine, All India Institute of Medical Sciences, Bhubaneswar, IND.
Internal Medicine, All India Institute of Medical Sciences, Bhubaneswar, IND.
Cureus. 2020 Sep 20;12(9):e10552. doi: 10.7759/cureus.10552.
Aluminum phosphide is a common suicidal agent in an agrarian country like India. Toxicity is mostly due to the liberation of phosphine gas, which non-competitively inhibits cytochrome oxidase in the mitochondria causing cell hypoxia. It can involve almost any organ in the body, but the most common is cardiovascular system. Various cardiovascular manifestations are hypotension, myocarditis, pericarditis, congestive heart failure, various ECG changes like myocardial infarction, conduction abnormalities, various arrhythmias, and very rarely unmasking of the Brugada pattern. Here we are presenting a case in which the patient developed unmasking of the Brugada pattern in ECG, and gradually he improved symptomatically and ECG wise with conservative treatment. As unmasking of the Brugada pattern in ECG can lead to life-threatening arrhythmias, one has to be cautious and keep this in mind while dealing with a case of aluminum phosphide poisoning.
在印度这样的农业国家，磷化铝是一种常见的自杀性毒物。中毒主要是由于磷化氢气体的释放，它非竞争性抑制线粒体中的细胞色素氧化酶，导致细胞缺氧。它几乎可累及身体的任何器官，但最常见的是心血管系统。各种心血管表现包括低血压、心肌炎、心包炎、充血性心力衰竭、各种心电图改变，如心肌梗死、传导异常、各种心律失常，以及极罕见的Brugada波型的显露。在此，我们报告一例患者，其心电图出现Brugada波型的显露，经保守治疗后症状及心电图均逐渐改善。由于心电图中Brugada波型的显露可导致危及生命的心律失常，在处理磷化铝中毒病例时必须谨慎并牢记这一点。
