Imbalzano Gabriele, Montanaro Elisa, Ledda Claudia, Donetto Francesca, D'Angelo Francesco, Campisi Corrado, Artusi Carlo Alberto, Romagnolo Alberto, Rizzone Mario Giorgio, Bozzali Marco, Lopiano Leonardo, Zibetti Maurizio
Department of Neuroscience "Rita Levi Montalcini", University of Torino, Turin, Italy.
SC Neurologia 2U, AOU Città della Salute e della Scienza, Turin, Italy.
Mov Disord. 2025 Jun;40(6):1189-1194. doi: 10.1002/mds.30218. Epub 2025 May 5.
High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves Parkinson's disease (PD) motor symptoms but may deteriorate verbal fluency (VF). Theta stimulation showed potential cognitive benefits associated with motor worsening.
This randomized, double-blind, crossover study evaluated the efficacy and safety of combined theta-gamma frequency stimulation on VF in PD patients with STN-DBS.
Patients were randomized 1:1 for standard or theta-gamma stimulation. VF, motor, and non-motor symptoms were assessed at baseline, 1 h, and 1 month after each period. Data were analyzed using a linear mixed-effects model.
Twelve patients completed the study. Non-episodic (P = 0.038) and episodic VF (P = 0.030) improved after 1 month of theta-gamma stimulation, while phonemic and switching fluency were unchanged. Motor and non-motor outcomes were unaffected by the stimulation, with mild adverse events.
Combined theta-gamma stimulation may enhance VF in PD patients with STN-DBS without worsening motor symptoms or safety concerns. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
丘脑底核（STN）的高频深部脑刺激（DBS）可改善帕金森病（PD）的运动症状，但可能会使言语流畅性（VF）恶化。θ刺激显示出与运动恶化相关的潜在认知益处。
这项随机、双盲、交叉研究评估了联合θ-γ频率刺激对接受STN-DBS治疗的PD患者VF的疗效和安全性。
患者按1:1随机分组接受标准刺激或θ-γ刺激。在每个阶段的基线、1小时和1个月后评估VF、运动和非运动症状。使用线性混合效应模型分析数据。
12名患者完成了研究。θ-γ刺激1个月后，非发作性（P = 0.038）和发作性VF（P = 0.030）有所改善，而音素流畅性和转换流畅性未改变。运动和非运动结果不受刺激影响，有轻度不良事件。
联合θ-γ刺激可能会增强接受STN-DBS治疗的PD患者的VF，而不会使运动症状恶化或产生安全问题。© 2025作者。《运动障碍》由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
