丘脑底核θ-γ刺激对帕金森病言语流畅性的影响：一项随机交叉试验

Theta-Gamma Subthalamic Stimulation for Verbal Fluency in Parkinson's Disease: A Randomized, Crossover Trial.

作者信息

Imbalzano Gabriele, Montanaro Elisa, Ledda Claudia, Donetto Francesca, D'Angelo Francesco, Campisi Corrado, Artusi Carlo Alberto, Romagnolo Alberto, Rizzone Mario Giorgio, Bozzali Marco, Lopiano Leonardo, Zibetti Maurizio

机构信息

Department of Neuroscience "Rita Levi Montalcini", University of Torino, Turin, Italy.

SC Neurologia 2U, AOU Città della Salute e della Scienza, Turin, Italy.

出版信息

Mov Disord. 2025 Jun;40(6):1189-1194. doi: 10.1002/mds.30218. Epub 2025 May 5.

DOI:10.1002/mds.30218

PMID:40322847

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12160985/

Abstract

BACKGROUND

High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves Parkinson's disease (PD) motor symptoms but may deteriorate verbal fluency (VF). Theta stimulation showed potential cognitive benefits associated with motor worsening.

OBJECTIVES

This randomized, double-blind, crossover study evaluated the efficacy and safety of combined theta-gamma frequency stimulation on VF in PD patients with STN-DBS.

METHODS

Patients were randomized 1:1 for standard or theta-gamma stimulation. VF, motor, and non-motor symptoms were assessed at baseline, 1 h, and 1 month after each period. Data were analyzed using a linear mixed-effects model.

RESULTS

Twelve patients completed the study. Non-episodic (P = 0.038) and episodic VF (P = 0.030) improved after 1 month of theta-gamma stimulation, while phonemic and switching fluency were unchanged. Motor and non-motor outcomes were unaffected by the stimulation, with mild adverse events.

CONCLUSION

Combined theta-gamma stimulation may enhance VF in PD patients with STN-DBS without worsening motor symptoms or safety concerns. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

摘要