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Transport and inhibition mechanisms of human creatine transporter.

作者信息

Chen Jiahui, Zhang Yimin, Chen Nanhao, Ge Jingpeng, Yu Jie

机构信息

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

University of Chinese Academy of Sciences, Beijing, China.

出版信息

Cell Discov. 2025 May 5;11(1):43. doi: 10.1038/s41421-025-00801-4.

DOI:10.1038/s41421-025-00801-4
PMID:40325013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12053652/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6d/12053652/9c080dc698ee/41421_2025_801_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6d/12053652/9c080dc698ee/41421_2025_801_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f6d/12053652/9c080dc698ee/41421_2025_801_Fig1_HTML.jpg

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本文引用的文献

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Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.人多巴胺转运体的多巴胺再摄取和抑制机制。
Nature. 2024 Aug;632(8025):686-694. doi: 10.1038/s41586-024-07796-0. Epub 2024 Aug 7.
2
Transport mechanism and pharmacology of the human GlyT1.人 GlyT1 的转运机制和药理学。
Cell. 2024 Mar 28;187(7):1719-1732.e14. doi: 10.1016/j.cell.2024.02.026. Epub 2024 Mar 20.
3
Creatine Activity as a Neuromodulator in the Central Nervous System.肌酸作为中枢神经系统中的神经调质。
Arch Razi Inst. 2023 Aug 31;78(4):1169-1175. doi: 10.32592/ARI.2023.78.4.1169. eCollection 2023 Aug.
4
Molecular basis for substrate recognition and transport of human GABA transporter GAT1.人 GABA 转运蛋白 GAT1 的底物识别和转运的分子基础。
Nat Struct Mol Biol. 2023 Jul;30(7):1012-1022. doi: 10.1038/s41594-023-00983-z. Epub 2023 Jul 3.
5
Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human Creatine Transporter-1.底物与离子的协同结合驱动人类肌酸转运蛋白-1的正向循环。
Front Physiol. 2022 Jun 28;13:919439. doi: 10.3389/fphys.2022.919439. eCollection 2022.
6
Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.靶向 SLC6A8 肌氨酸转运蛋白治疗抑制结肠癌进展并调节人体肌氨酸水平。
Sci Adv. 2021 Oct 8;7(41):eabi7511. doi: 10.1126/sciadv.abi7511. Epub 2021 Oct 6.
7
Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.4-苯基丁酸酯对几种与肌氨酸转运蛋白缺乏症相关的错误折叠肌氨酸转运蛋白 1 变体的挽救作用。
Neuropharmacology. 2019 Dec 15;161:107572. doi: 10.1016/j.neuropharm.2019.03.015. Epub 2019 Mar 15.
8
Creatine biosynthesis and transport in health and disease.健康与疾病状态下的肌酸生物合成及转运
Biochimie. 2015 Dec;119:146-65. doi: 10.1016/j.biochi.2015.10.022. Epub 2015 Nov 2.
9
Synthesis and transport of creatine in the CNS: importance for cerebral functions.中枢神经系统中肌酸的合成与转运:对脑功能的重要性。
J Neurochem. 2010 Oct;115(2):297-313. doi: 10.1111/j.1471-4159.2010.06935.x. Epub 2010 Aug 25.
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Epilepsy spectrum in cerebral creatine transporter deficiency.脑肌酸转运体缺乏症中的癫痫谱系
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