Grimes Pearl, Hamzavi Iltefat H, Bibeau Kristen, Harris John E, van Geel Nanja, Parsad Davinder, Gardner Jackie, Valle Yan, Tlhong Matewa Gaone, Gao Jessy, Ren Haobo, Ezzedine Khaled
Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Blvd Suite 650, Los Angeles, CA, 90036, USA.
Henry Ford Medical Center, Detroit, MI, USA.
Dermatol Ther (Heidelb). 2025 Jul;15(7):1931-1939. doi: 10.1007/s13555-025-01412-3. Epub 2025 May 5.
Factors associated with vitiligo burden in patients with darker skin (Fitzpatrick skin types IV-VI) are not fully understood. This analysis of patients in the global VALIANT study examined the quality of life (QoL) and psychosocial health among patients with vitiligo by skin type.
Participants from 17 countries were surveyed regarding their clinical characteristics, everyday experiences with vitiligo, impact of vitiligo on daily activities, emotional well-being, and mental health.
Of 3541 surveyed patients, 40.8% (n = 1445) had darker skin versus 59.2% (n = 2096) with fairer skin (types I-III). Patients with darker skin had greater median disease extent than those with fairer skin (6.6% vs 2.5%; P < 0.0001). Mean Vitiligo Impact Patient scale scores were higher among patients with darker skin (31.2 vs 24.5; P < 0.0001); daily activities and emotional well-being were significantly more impacted among patients with darker skin. Among individual skin types, patients with types V and VI expressed considerably higher rates of burden versus all other skin types in all assessments. Interestingly, among patients with fairer skin, those with skin type I reported higher rates of burden than those with skin types II and III.
Patients with darker skin, particularly skin types V and VI, were more impacted in their daily lives, emotional well-being, and mental health than those with fairer skin, suggesting that a disproportionate need for strategies to improve QoL and mental health burden exists among patients with vitiligo who have skin of color.
深色皮肤（菲茨帕特里克皮肤分型IV - VI型）白癜风患者的疾病负担相关因素尚未完全明确。这项针对全球VALIANT研究中患者的分析，按皮肤类型研究了白癜风患者的生活质量（QoL）和心理社会健康状况。
对来自17个国家的参与者进行了调查，内容包括他们的临床特征、白癜风的日常经历、白癜风对日常活动的影响、情绪健康和心理健康。
在3541名接受调查的患者中，40.8%（n = 1445）为深色皮肤，而肤色较浅（I - III型）的患者占59.2%（n = 2096）。深色皮肤患者的疾病中位数范围比肤色较浅的患者更大（6.6%对2.5%；P < 0.0001）。深色皮肤患者的白癜风影响患者量表平均得分更高（31.2对24.5；P < 0.0001）；深色皮肤患者的日常活动和情绪健康受到的影响明显更大。在各个皮肤类型中，V型和VI型患者在所有评估中的负担率均显著高于所有其他皮肤类型。有趣的是，在肤色较浅的患者中，I型皮肤患者的负担率高于II型和III型皮肤患者。
与肤色较浅的患者相比，深色皮肤患者，尤其是V型和VI型皮肤患者，在日常生活、情绪健康和心理健康方面受到的影响更大，这表明有色人种白癜风患者对改善生活质量和心理健康负担策略的需求不成比例。
