Chen Joann J, Mermin Sam A, Duffy Lucie A, Wong Samantha A, Layfield Savannah D, Rodriguez-Villa Fernando, Gelda Steven E, Gelwan Eliot M, Eisen Jane, Ressler Kerry J, Choi-Kain Lois W, Yip Agustin G
University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gunderson Personality Disorders Institute, McLean Hospital, 115 Mill St, Belmont, MA, 02478, USA.
BMC Psychiatry. 2025 May 5;25(1):452. doi: 10.1186/s12888-025-06928-8.
Outpatient psychotherapies are gold standard interventions for borderline personality disorder (BPD); however, in clinical reality, higher rates of psychiatric hospitalization and more severe symptoms, including suicidality and self-harm, occur for those with BPD compared to those with other psychiatric disorders in inpatient units.
This study aims to distinguish the clinical profile and outcomes of patients screening positive for a threshold of BPD traits in the inpatient psychiatric setting using the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD), from those who do not.
Compared to those screening negative on the MSI-BPD (MSI-BPD-), those who screen positive (MSI-BPD +) are younger, more likely to be female, and more likely to report a range of health and psychosocial risk factors such as unstable housing, reduced educational attainment, physical health problems, past trauma, and problematic drug and alcohol use. MSI-BPD + patients report significantly higher severity of anxiety, depression, suicidality, self-harm, and global symptoms on admission than MSI-BPD- patients. In terms of response to inpatient care, they also self-report significantly greater improvements and higher proportions of reliable change on measures of anxiety, depression, and general psychiatric severity. At discharge, MSI-BPD + patients no longer report significantly higher suicidality but do report greater levels of thoughts of self-harm.
These findings suggest that patients with self-reported BPD symptoms experience acute symptom relief during short-term inpatient hospitalization, including for suicidality-related symptoms. Our study also demonstrates the feasibility of utilizing the MSI-BPD screening tool within a large adult inpatient psychiatric population to identify individuals likely to have BPD with distinct clinical profiles.
门诊心理治疗是边缘型人格障碍(BPD)的金标准干预措施;然而,在临床实际中,与住院部其他精神障碍患者相比,BPD患者的精神科住院率更高,症状更严重,包括自杀和自伤行为。
本研究旨在使用麦克莱恩边缘型人格障碍筛查工具(MSI-BPD),区分在住院精神科环境中筛查BPD特质阈值呈阳性的患者与未呈阳性患者的临床特征和治疗结果。
与MSI-BPD筛查呈阴性(MSI-BPD-)的患者相比,筛查呈阳性(MSI-BPD+)的患者更年轻,更可能为女性,更可能报告一系列健康和心理社会风险因素,如住房不稳定、教育程度降低、身体健康问题、既往创伤以及药物和酒精使用问题。MSI-BPD+患者入院时焦虑、抑郁、自杀、自伤和总体症状的严重程度显著高于MSI-BPD-患者。在对住院治疗的反应方面,他们在焦虑、抑郁和一般精神严重程度测量上的自我报告改善也显著更大,可靠变化比例更高。出院时,MSI-BPD+患者不再报告显著更高的自杀倾向,但确实报告了更高水平的自伤想法。
这些发现表明,自我报告有BPD症状的患者在短期住院治疗期间症状得到急性缓解,包括与自杀相关的症状。我们的研究还证明了在大量成年住院精神科患者中使用MSI-BPD筛查工具来识别可能患有BPD且具有不同临床特征的个体的可行性。