喉鳞状细胞癌中结外扩展分级的重要性
The Importance of Extranodal Extension Grading in Laryngeal Squamous Cell Carcinoma.
作者信息
Kara Hakan, Aydemir Levent, Büyük Melek, Bozbora Erol, Toraman Kübra Özkaya, Pamuk Saim, Avcı Kağan, Sen Comert, Sonmez Said, Ulusan Murat, Basaran Bora, Altun Musa, Kıyak Erkan
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Department of Pathology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
出版信息
Otolaryngol Head Neck Surg. 2025 Sep;173(3):660-670. doi: 10.1002/ohn.1297. Epub 2025 May 5.
OBJECTIVE
The primary objective was to investigate the effect of extra-nodal extension (ENE) grading on the survival of pN-positive patients with laryngeal squamous cell carcinoma (LSCC).
STUDY DESIGN
A retrospective cohort study.
SETTING
A tertiary referral center.
METHODS
The patients with LSCC were retrospectively reviewed. The histopathological slides of patients were re-examined, and ENE was graded. Survival analyses were performed.
RESULTS
Seventy-six patients were enrolled in this study. The average age of patients was 61.29 years. 3-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) rates were 69.7%, 73.7%, and 73.7%, respectively. ENE grading had no statistically significant impact on survival rates.
CONCLUSION
While the presence of ENE in more than 4 lymph nodes, lymph node density (LND) greater than 0.2, poor histologic differentiation, and not receiving chemotherapy were identified as independent poor prognosticators in LSCC, the study did not show any effect of ENE grading on survival rates.
目的
主要目的是研究喉鳞状细胞癌（LSCC）pN阳性患者的结外扩展（ENE）分级对生存的影响。
研究设计
一项回顾性队列研究。
研究地点
一家三级转诊中心。
方法
对LSCC患者进行回顾性分析。重新检查患者的组织病理切片并对ENE进行分级。进行生存分析。
结果
本研究共纳入76例患者。患者的平均年龄为61.29岁。3年总生存率（OS）、疾病特异性生存率（DSS）和无病生存率（DFS）分别为69.7%、73.7%和73.7%。ENE分级对生存率无统计学显著影响。
结论
虽然在LSCC中，4个以上淋巴结存在ENE、淋巴结密度（LND）大于0.2、组织学分化差以及未接受化疗被确定为独立的不良预后因素，但该研究未显示ENE分级对生存率有任何影响。
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