Atallah M T, Barbeau I S, Pellett P L
J Nutr. 1977 Apr;107(4):650-5. doi: 10.1093/jn/107.4.650.
During gestation and lactation, the food intake of female rats was restricted to 50% of the ad libitum stock diet intake of controls (C). One restricted group (M1) was fed stock diet while another restricted group (M2) was fed casein-supplemented stock diet containing 66% protein. Observations were directed to their progeny. After weaning at 21 days, all progeny were fed the stock diet ad libitum for 2 weeks. Mean birth weight of M2 was lower than M1 which was lower than C. Weight gain of progeny was faster in M2 than M1 but both were less than C. At 5 weeks, M2 had normal brain weight but lower mg protein/g brain than either M1 or C. M1 had the lowest brain weight. Livers of M1 and M2 were smaller than C, and M2 had higher RNA and protein, and lower DNA per g liver than either M1 or C. Both M1 and M2 had about three-fold elevation in hepatic serine dehydratase and slightly lower phosphoglycerate dehydrogenase than C. The lower birth weight and normal brain size of M2 suggested that some of the protein consumed by M2 dams was conserved for synthesis of vital components despite energy restriction.
在妊娠期和哺乳期，雌性大鼠的食物摄入量被限制为对照组（C）自由采食基础日粮摄入量的50%。一个限制组（M1）饲喂基础日粮，而另一个限制组（M2）饲喂补充了酪蛋白的基础日粮，其蛋白质含量为66%。观察对象为它们的后代。在21日龄断奶后，所有后代自由采食基础日粮2周。M2组的平均出生体重低于M1组，M1组低于C组。M2组后代的体重增加速度比M1组快，但两组均低于C组。在5周龄时，M2组的脑重正常，但每克脑组织中的蛋白质毫克数低于M1组和C组。M1组的脑重最低。M1组和M2组的肝脏比C组小，并且M2组每克肝脏中的RNA和蛋白质含量更高，DNA含量低于M1组和C组。M1组和M2组的肝脏丝氨酸脱水酶水平均升高约三倍，磷酸甘油酸脱氢酶水平略低于C组。M2组较低的出生体重和正常的脑大小表明，尽管存在能量限制，但M2组母鼠摄入的一些蛋白质被保留用于合成重要成分。
