Saharawat Sakshi, Verma Sushma
Pharmacy Institute, Noida Institute of Engineering and Technology, Uttar Pradesh, Greater Noida, India.
Recent Pat Nanotechnol. 2025;19(3):364-380. doi: 10.2174/0118722105259776231002071218.
Niosomes are novel, self-assembled vesicular carriers that deliver both lipophilic and hydrophilic drugs at the specific site in a targeted way, enhancing bioavailability and extending therapeutic effects. Niosomes are a versatile drug delivery system with a diverse range of applications from gene to brain-targeted delivery and they are more attractive choices than liposomes as they are efficient at biodegrading. Niosome offers several advantages over conventional drug delivery systems, including enhanced stability, and also have gained a lot of focus in natural product delivery in recent years. This review provides a comprehensive view of niosomal research and recent advancements, including classification and fabrication methods, and their role in drug delivery and targeting. The description of the rise in niosomal formulation patents around the world is also elaborated along with the natural product delivery of niosomes which has recently gained significance. Patents on novel preparation, loading, and modification techniques have enhanced the importance of niosome in the pharmaceutical industry.
非离子表面活性剂泡囊是新型的自组装囊泡载体，能够以靶向方式将亲脂性药物和亲水性药物递送至特定部位，提高生物利用度并延长治疗效果。非离子表面活性剂泡囊是一种多功能药物递送系统，具有从基因传递到脑靶向递送等广泛的应用，并且由于其在生物降解方面效率高，比脂质体更具吸引力。与传统药物递送系统相比，非离子表面活性剂泡囊具有多个优点，包括稳定性增强，近年来在天然产物递送方面也备受关注。本综述全面介绍了非离子表面活性剂泡囊的研究及最新进展，包括分类和制备方法，以及它们在药物递送和靶向中的作用。还阐述了全球非离子表面活性剂泡囊制剂专利数量的增长情况，以及最近在天然产物递送方面具有重要意义的非离子表面活性剂泡囊。新型制备、负载和修饰技术的专利提高了非离子表面活性剂泡囊在制药行业的重要性。
