突发性感音神经性听力损失中全免疫炎症值和淋巴细胞单核细胞比值的检测
Examination of Pan-Immune-Inflammation Value and Lymphocyte-Monocyte Ratio in Sudden Sensorineural Hearing Loss.
作者信息
Akin V, Yasan H, Sivrice M E, Kumbul Y Ç
机构信息
Department of Otorhinolaryngology and Head and Neck Surgery, Yüksekova State Hospital, Hakkari, Türkiye.
Department of Otorhinolaryngology and Head and Neck Surgery, Süleyman Demirel University Faculty of Medicine, Isparta, Türkiye.
出版信息
Niger J Clin Pract. 2025 Feb 1;28(2):243-247. doi: 10.4103/njcp.njcp_246_24. Epub 2025 Mar 27.
BACKGROUND
Studies about inflammation indices are becoming increasingly common. Inflammation is thought to play an important role in the aetiopathogenesis of sudden sensorineural hearing loss.
AIM
In this study, we aimed to compare sudden sensorineural hearing loss patients and patients in a control group in terms of pan-immune-inflammation value and lymphocyte-monocyte ratio and to determine the relationship of these indices with sudden sensorineural hearing loss.
METHODS
The research was designed as a retrospective, case-control study. The archival records of patients diagnosed with sudden sensorineural hearing loss between 1 January 2018 and 1 May 2023 were scanned. Within the scope of the study, age, gender, amount of hearing loss, hearing loss accompanied by vertiginous symptoms, hearing loss accompanied by tinnitus, full blood count results, pan-immune-inflammation value and lymphocyte-monocyte ratio were analysed between the groups. Statistical analyses were performed using the independent samples t-test, Chi-square test and Pearson correlation analysis.
RESULTS
Leukocyte, neutrophil, platelet and pan-immune-inflammation values were found to be significantly higher in patients with sudden sensorineural hearing loss (P values: 0.023, <0.001, 0.010, <0.001, respectively). Lymphocyte and monocyte values were significantly lower (P values: <0.001, 0.006, respectively). There was no significant difference in terms of lymphocyte-monocyte ratio (P = 0.455). There was no relationship between tinnitus, vertiginous symptoms and blood parameters. There was a positive correlation between neutrophil value and the amount of hearing loss (P = 0.036).
CONCLUSION
In our study, the pan-immune-inflammation value was significantly higher in sudden sensorineural hearing loss patients. A statistically significant relationship was detected between high neutrophil values and the amount of hearing loss. These results can be evaluated on the basis of the inflammation-ischaemia relationship in the aetiopathogenesis of sudden sensorineural hearing loss.
背景
关于炎症指标的研究日益普遍。炎症被认为在突发性感音神经性听力损失的病因发病机制中起重要作用。
目的
在本研究中，我们旨在比较突发性感音神经性听力损失患者和对照组患者的全免疫炎症值和淋巴细胞与单核细胞比值，并确定这些指标与突发性感音神经性听力损失的关系。
方法
本研究设计为一项回顾性病例对照研究。扫描了2018年1月1日至2023年5月1日期间诊断为突发性感音神经性听力损失患者的档案记录。在研究范围内，对两组患者的年龄、性别、听力损失程度、伴有眩晕症状的听力损失、伴有耳鸣的听力损失、全血细胞计数结果、全免疫炎症值和淋巴细胞与单核细胞比值进行了分析。使用独立样本t检验、卡方检验和Pearson相关分析进行统计分析。
结果
发现突发性感音神经性听力损失患者的白细胞、中性粒细胞、血小板和全免疫炎症值显著更高（P值分别为：0.023、<0.001、0.010、<0.001）。淋巴细胞和单核细胞值显著更低（P值分别为：<0.001、0.006）。淋巴细胞与单核细胞比值方面无显著差异（P = 0.455）。耳鸣、眩晕症状与血液参数之间无相关性。中性粒细胞值与听力损失程度之间存在正相关（P = 0.036）。
结论
在我们的研究中，突发性感音神经性听力损失患者的全免疫炎症值显著更高。检测到高中性粒细胞值与听力损失程度之间存在统计学显著关系。这些结果可基于突发性感音神经性听力损失病因发病机制中的炎症 - 缺血关系进行评估。
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