Tomiyama H, Yamagiwa H
Gan No Rinsho. 1985 Jun;31(7):827-32.
Six hundred cases of resected gallbladder were histologically investigated by serial sections for intestinal (goblet cell) metaplasia and pseudopyloric gland metaplasia. Intestinal metaplasia was found at the rates of 4.8% and 30.0% in the stone-free cases and those with bile duct stone, respectively. It was found at rates of 52.0% in cases of gallbladder carcinoma. On the other hand, goblet cell-like cells were found at the rates of 35.0% and 26.0% in the tissues of carcinoma and dysplasia, respectively. Although the normal epithelium of the gallbladder has sulfomucin, goblet cells contain sialomucin. The ratio of sialomucin-containing cells increased in dysplasia and carcinoma. Pseudopyloric gland metaplasia was found at the rates of 46.0 and 70.0% in the stone-free cases and those with bile duct stone, respectively. However, it should be considered that this change has less of a relationship with the bases of carcinogenesis than with those of intestinal metaplasia.
对600例切除的胆囊进行了组织学研究，通过连续切片观察肠道（杯状细胞）化生和假幽门腺化生情况。在无结石病例和胆管结石病例中，肠道化生的发生率分别为4.8%和30.0%。在胆囊癌病例中，其发生率为52.0%。另一方面，在癌组织和发育异常组织中，杯状细胞样细胞的发生率分别为35.0%和26.0%。虽然胆囊的正常上皮含有硫黏液，但杯状细胞含有涎黏液。在发育异常和癌组织中，含涎黏液细胞的比例增加。假幽门腺化生在无结石病例和胆管结石病例中的发生率分别为46.0%和70.0%。然而，应该认为这种变化与致癌基础的关系较小，而与肠道化生的关系较大。
