Kanavati Sam, Chandra Aman, Zhang Jufen, Charteris David G, Yorston David, Casswell Edward J
Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Southend Hospital Eye Unit, Southend University Hospital, Southend-on-Sea, United Kingdom.
Retina. 2025 Apr 29. doi: 10.1097/IAE.0000000000004503.
To explore the effect of subretinal fluid drainage on the amplitude of retinal displacement and distortion following macula-involving retinal detachment repair.
Post hoc analysis of the PostRD trial - patients who underwent a drainage retinotomy at the surgeon's discretion were compared to break drainage. Primary outcome - amplitude of retinal displacement on autofluorescence imaging at 6 months postoperatively. Secondary outcome measures - operative success; visual acuity; objective Distortion Scores & OCT imaging outcomes.
262 patients recruited, 69 underwent drainage retinotomy. Re-detachment occurred in 11/69 (16%) of the retinotomy group versus 12/193 (6%) of the non-retinotomy group. Regression analysis revealed the extent of RD to be the only risk factor for failure. Failures were excluded. At 6 months, the retinotomy group had a lower amplitude of retinal displacement (P 0.02). Multivariable regression analysis showed that face down positioning and drainage retinotomy were both independent predictors for reducing amplitude of retinal displacement (P <0.01 and P 0.038) respectively, whilst extent of RD was a significant predictor for an increase in displacement (P 0.003).Visual acuity was higher in the retinotomy group (77 letters vs 74 non-retinotomy P 0.04) but similar when phakic patients were excluded (P 0.35). Objective D-Chart Distortion scores were lower (p=0.002). Retinal folds were more common in the retinotomy group (14.5% vs 8.7% non-retinotomy [P 0.004]).
Retinotomy may be associated with a lower amplitude of displacement and lower distortion despite a higher incidence of retinal folds. No association was found between retinotomy and retinal re-detachment.
探讨视网膜下液引流对累及黄斑的视网膜脱离修复术后视网膜移位幅度和变形的影响。
对PostRD试验进行事后分析——将根据外科医生的判断进行引流视网膜切开术的患者与裂孔引流患者进行比较。主要结局——术后6个月时自体荧光成像上的视网膜移位幅度。次要结局指标——手术成功率;视力;客观变形评分和光学相干断层扫描(OCT)成像结果。
招募了262例患者,69例行引流视网膜切开术。视网膜切开术组11/69(16%)发生再脱离,而非视网膜切开术组12/193(6%)发生再脱离。回归分析显示视网膜脱离范围是失败的唯一危险因素。排除失败病例。6个月时,视网膜切开术组的视网膜移位幅度较低(P = 0.02)。多变量回归分析表明,面朝下体位和引流视网膜切开术分别是降低视网膜移位幅度的独立预测因素(P <0.01和P = 0.038),而视网膜脱离范围是移位增加的显著预测因素(P = 0.003)。视网膜切开术组的视力较高(77个字母对非视网膜切开术组的74个字母,P = 0.04),但排除有晶状体眼患者后相似(P = 0.35)。客观D图表变形评分较低(p = 0.002)。视网膜褶皱在视网膜切开术组更常见(14.5%对非视网膜切开术组的8.7%[P = 0.004])。
尽管视网膜褶皱发生率较高,但视网膜切开术可能与较低的移位幅度和较低的变形有关。未发现视网膜切开术与视网膜再脱离之间存在关联。