• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effects of methamphetamine on dopamine cells in the substantia nigra pars compacta and the ventral tegmental area.

作者信息

Kamata K, Kameyama T

出版信息

Jpn J Pharmacol. 1985 Jun;38(2):231-4. doi: 10.1254/jjp.38.231.

DOI:10.1254/jjp.38.231
PMID:4032860
Abstract

The ability of methamphetamine to inhibit the firing rate of dopamine cells in the substantia nigra pars compacta (SNC) and the ventral tegmental area (VTA) was studied. Methamphetamine reduced the firing rates of the dopamine cells in a dose-dependent manner in the SNC and the VTA. The doses of methamphetamine required to produce a 50% inhibition of firing rate in the SNC and the VTA were 0.37 mg/kg and 0.28 mg/kg, respectively.

摘要

相似文献

1
Effects of methamphetamine on dopamine cells in the substantia nigra pars compacta and the ventral tegmental area.
Jpn J Pharmacol. 1985 Jun;38(2):231-4. doi: 10.1254/jjp.38.231.
2
Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons.N-正丙基去甲阿扑吗啡对映体对黑质致密部和腹侧被盖区多巴胺能神经元单单位活动的影响。
J Pharmacol Exp Ther. 1988 Oct;247(1):355-62.
3
Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area.通过黑质致密部和腹侧被盖区介导大鼠脑片细胞放电抑制的多巴胺受体药理学比较。
Br J Pharmacol. 1994 Jul;112(3):873-80. doi: 10.1111/j.1476-5381.1994.tb13161.x.
4
Effect of chronic treatment with SCH 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in rats.SCH 23390和氟哌啶醇长期治疗对大鼠黑质致密部（SNC）和腹侧被盖区（VTA）多巴胺神经元自发活动的影响。
Eur J Pharmacol. 1988 Jan 12;145(2):239-43. doi: 10.1016/0014-2999(88)90238-5.
5
Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats.氟哌啶醇、氯氮平、硫利达嗪和替氟哒嗪反复治疗对大鼠中脑黑质和腹侧被盖区多巴胺能神经元的不同影响。
Life Sci. 1988;42(10):1037-44. doi: 10.1016/0024-3205(88)90558-9.
6
Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area.
Brain Res. 1985 Nov 25;348(1):201-3. doi: 10.1016/0006-8993(85)90381-6.
7
Correlation between the discharge rate of non-dopamine neurons in substantia nigra and ventral tegmental area and the motor activity induced by apomorphine.黑质和腹侧被盖区非多巴胺能神经元的放电率与阿扑吗啡诱导的运动活动之间的相关性。
Neuroscience. 1988 Feb;24(2):465-76. doi: 10.1016/0306-4522(88)90342-9.
8
Amphetamine-induced increase in motor activity is correlated with higher firing rates of non-dopamine neurons in substantia nigra and ventral tegmental area.苯丙胺引起的运动活动增加与黑质和腹侧被盖区非多巴胺能神经元的较高放电率相关。
Neuroscience. 1988 Feb;24(2):477-90. doi: 10.1016/0306-4522(88)90343-0.
9
Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats.缰核损伤减弱甲基苯丙胺对大鼠黑质致密部多巴胺能神经元活动的抑制作用。
Neurosci Lett. 1988 Mar 21;86(1):67-71. doi: 10.1016/0304-3940(88)90184-x.
10
Inhibition of non-dopamine cells in the ventral tegmental area by benzodiazepines: relationship to A10 dopamine cell activity.苯二氮䓬类药物对腹侧被盖区非多巴胺能细胞的抑制作用：与A10多巴胺能细胞活性的关系。
Eur J Pharmacol. 1987 Oct 27;142(3):343-54. doi: 10.1016/0014-2999(87)90072-0.

引用本文的文献

1
Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione.长期吸食冰毒会增加中脑边缘系统线粒体的耗氧量，并降低纹状体谷胱甘肽的水平。
Neuropharmacology. 2023 Apr 1;227:109436. doi: 10.1016/j.neuropharm.2023.109436. Epub 2023 Jan 21.
2
Neurotensin receptor 1 deletion decreases methamphetamine self-administration and the associated reduction in dopamine cell firing.神经降压素受体 1 缺失可减少甲基苯丙胺的自我给药，并降低多巴胺能神经元的放电。
Addict Biol. 2021 Jan;26(1):e12854. doi: 10.1111/adb.12854. Epub 2019 Nov 19.
3
Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice.
腹侧被盖区神经降压素受体拮抗作用可减少小鼠甲基苯丙胺的自身给药和觅药行为。
Int J Neuropsychopharmacol. 2018 Apr 1;21(4):361-370. doi: 10.1093/ijnp/pyx117.
4
Comparison of systemic and local methamphetamine treatment on acetylcholine and dopamine levels in the ventral tegmental area in the mouse.小鼠腹侧被盖区中全身和局部甲基苯丙胺治疗对乙酰胆碱和多巴胺水平的比较。
Neuroscience. 2008 Oct 15;156(3):700-11. doi: 10.1016/j.neuroscience.2008.07.052. Epub 2008 Aug 3.
5
Effect of chronic administration of methamphetamine on the responsiveness of substantia nigra zona reticulata neurons to GABA or a GABA agonist in rats.长期给予甲基苯丙胺对大鼠黑质网状带神经元对γ-氨基丁酸（GABA）或GABA激动剂反应性的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):458-62. doi: 10.1007/BF00569386.