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肺动脉导管插入术的应用与外科手术患者预后的关联:一项遵循PRISMA标准的系统评价和荟萃分析。

The association of pulmonary artery catheterization utilization and surgical patients' outcomes: a PRISMA-compliant systematic review and meta-analysis.

作者信息

Xie Chun-Mei, He Li-Xian, Shen Meng-Qi, Yao Yun-Tai

机构信息

Department of Anesthesiology, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, 650102, China.

Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100037, China.

出版信息

J Cardiothorac Surg. 2025 May 6;20(1):227. doi: 10.1186/s13019-025-03416-8.

Abstract

BACKGROUND

The utilization of pulmonary artery catheterization (PAC) in surgical patients remains controversial. This study aims to assess the impact of PAC utilization on surgical patient outcomes.

METHODS

Electronic databases were searched for studies comparing PAC with no-PAC in surgical patients. The primary outcome was short-term mortality. Secondary outcomes included the incidence of postoperative complications, postoperative recovery indicators, and hospitalization costs.

RESULTS

Ten randomized controlled trials (n = 2,889) and sixteen observational studies (n = 2,221,917) were included. Among these studies, fifteen involved cardiac surgical patients (n = 2,217,736), and eleven involved non-cardiac surgical patients (n = 7,070). The present study demonstrated PAC utilization did not affect short-term mortality in cardiac surgical patients [odds ratio (OR) 1.20, 95% confidence interval (CI) 0.79-1.82, p 0.40], and was associated with a higher incidence of postoperative chronic heart failure, acute renal failure, cerebrovascular events, infectious complications, and longer length of stay (LOS) in intensive care unit (ICU) or hospital. Moreover, PAC utilization was not associated with short-term mortality (OR 0.40, 95% CI 0.16-1.02, p 0.06) and other outcomes for non-cardiac surgical patients.

CONCLUSIONS

This meta-analysis suggested PAC utilization was not associated with short-term mortality in surgical patients but with a higher incidence of major complications and longer LOS in the ICU or hospital in cardiac surgical patients.

摘要

背景

肺动脉导管插入术(PAC)在外科手术患者中的应用仍存在争议。本研究旨在评估PAC的应用对外科手术患者预后的影响。

方法

检索电子数据库,查找比较外科手术患者使用PAC与未使用PAC的研究。主要结局为短期死亡率。次要结局包括术后并发症的发生率、术后恢复指标和住院费用。

结果

纳入了10项随机对照试验(n = 2889)和16项观察性研究(n = 2221917)。在这些研究中,15项涉及心脏外科手术患者(n = 2217736),11项涉及非心脏外科手术患者(n = 7070)。本研究表明,在心脏外科手术患者中,使用PAC并不影响短期死亡率[优势比(OR)为1.20,95%置信区间(CI)为0.79 - 1.82,p = 0.40],且与术后慢性心力衰竭、急性肾衰竭、脑血管事件、感染性并发症的发生率较高以及重症监护病房(ICU)或医院的住院时间延长有关。此外,对于非心脏外科手术患者,使用PAC与短期死亡率(OR = 0.40,95% CI为0.16 - 1.02,p = 0.06)及其他结局无关。

结论

这项荟萃分析表明,在外科手术患者中,使用PAC与短期死亡率无关,但在心脏外科手术患者中,与主要并发症的发生率较高以及在ICU或医院的住院时间延长有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86c9/12054134/fba2d42c88c0/13019_2025_3416_Fig1_HTML.jpg

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