Destek Sabahattin, Demirbolat İlker, Yabacı Ayşegül, Kalemoglu Murat, Kartal Murat, Ersoy Emine Yeliz, Gul Vahit Onur, Kayıran Zulal, Aysan Mustafa Erhan
Department of General Surgery, Üsküdar University School of Medicine, Istanbul, Turkey.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kent University, Istanbul, Turkey.
J Med Food. 2025 Jul;28(7):668-672. doi: 10.1089/jmf.2024.0263. Epub 2025 May 12.
Thyroid nodules are common and affect half of the general population by the age of 60 years. The cause is believed to be due to hypothyroidism, mutational changes, and autoimmunity leading to thyroid carcinoma. Dill, a traditional herbal remedy, has been used to treat thyroid dysfunctions such as hyperthyroidism and hypothyroidism. This study evaluates the effects of dill () on patients with thyroiditis and nodular goiter. A study was conducted on patients with benign thyroid nodules. They were divided into two groups; placebo (=35) and dill group ( = 33). Dried and ground dill was put into hydroxypropyl methylcellulose capsules and patients were given three capsules per day for 90 days. Various tests were conducted at the beginning and end of the study, including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-Tg), and C-reactive protein (CRP) analysis, and thyroid nodule dimensions were measured by ultrasound. Statistical analysis was performed. After 90 days of treatment with dill extract, patients showed significant reductions in TSH, FT4, anti-TPO, and CRP levels, as well as a decrease in thyroid nodule sizes as demonstrated by ultrasonography. The dill-treated group had significantly decreased TSH ( = .020), FT4 ( = .001), anti-TPO ( = .004), CRP ( = .003) levels, and nodule sizes ( = .001) at the beginning and end of the study. Compared to the control group, the dill group had significantly decreased TSH ( = .009), fT4 ( < .001), anti-TPO ( = .001), CRP ( < .001) levels and nodule sizes ( < .001), which reached normal values. suppressed inflammation of the thyroid gland, reduced nodule size, and normalized TSH levels. Dill supplementation should be recommended for the treatment of thyroid nodules in selected patients.
甲状腺结节很常见，到60岁时，一般人群中有一半会受到影响。其病因被认为是由于甲状腺功能减退、突变变化以及导致甲状腺癌的自身免疫。莳萝是一种传统草药，已被用于治疗甲状腺功能障碍，如甲状腺功能亢进和甲状腺功能减退。本研究评估了莳萝（）对甲状腺炎和结节性甲状腺肿患者的影响。对患有良性甲状腺结节的患者进行了一项研究。他们被分为两组；安慰剂组（=35）和莳萝组（=33）。将干燥磨碎的莳萝装入羟丙基甲基纤维素胶囊中，患者每天服用三粒胶囊，持续90天。在研究开始和结束时进行了各种测试，包括促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、抗甲状腺过氧化物酶（抗TPO）、抗甲状腺球蛋白（抗Tg）和C反应蛋白（CRP）分析，并通过超声测量甲状腺结节尺寸。进行了统计分析。用莳萝提取物治疗90天后，患者的TSH、FT4、抗TPO和CRP水平显著降低，超声检查显示甲状腺结节大小减小。莳萝治疗组在研究开始和结束时，TSH（=0.020）、FT4（=0.001）、抗TPO（=0.004）、CRP（=0.003）水平和结节大小（=0.001）显著降低。与对照组相比，莳萝组的TSH（=0.009）、fT4（<0.001）、抗TPO（=0.001）、CRP（<0.001）水平和结节大小（<0.001）显著降低，且达到正常水平。莳萝抑制了甲状腺炎症，减小了结节大小，并使TSH水平正常化。对于选定患者的甲状腺结节治疗，建议补充莳萝。
