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乳糜泻危象:成人乳糜泻的一例罕见医疗紧急情况病例报告

Celiac Crisis: A Rare Medical Emergency Case Report in Adult Celiac Disease.

作者信息

Musleh Mais, AlMokbel Amani

机构信息

Department of Hematology, Faculty of Medicine, Damascus University, Damascus, Syria.

Department of Gastroenterology, Faculty of Medicine, Damascus University, Damascus, Syria.

出版信息

Case Rep Gastrointest Med. 2025 Apr 28;2025:6259846. doi: 10.1155/crgm/6259846. eCollection 2025.

Abstract

Celiac crisis (CC) is a rare but potentially life-threatening complication of celiac disease (CD), characterized by severe diarrhea, electrolyte imbalances, and metabolic disturbances. We report the case of a 32-year-old pregnant woman presented significant dehydration, weight loss, and steatorrheic stools. Diagnosis was confirmed by duodenal biopsy, with rapid improvement following a gluten-free diet (GFD) and corticosteroids. The diagnosis of CC was established based on the acute clinical presentation and rapid improvement following a GFD and corticosteroid therapy. This case highlights the importance of early recognition and prompt management of CC, particularly in undiagnosed or untreated CD, to prevent severe maternal and fetal complications.

摘要

乳糜泻危象(CC)是乳糜泻(CD)一种罕见但可能危及生命的并发症,其特征为严重腹泻、电解质失衡和代谢紊乱。我们报告了一例32岁孕妇,出现明显脱水、体重减轻和脂肪泻。十二指肠活检确诊,采用无麸质饮食(GFD)和皮质类固醇后病情迅速改善。CC的诊断基于急性临床表现以及GFD和皮质类固醇治疗后的快速改善。该病例强调了早期识别和及时处理CC的重要性,尤其是在未诊断或未治疗的CD中,以预防严重的母婴并发症。

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本文引用的文献

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ACG Guideline: Diagnosis and Management of Celiac Disease.美国胃肠病学会指南:乳糜泻的诊断与管理
Am J Gastroenterol. 2023 Jan 1;118(1):23. doi: 10.14309/ajg.0000000000002111. Epub 2022 Sep 16.
6
A simple phenotypic classification for celiac disease.一种用于乳糜泻的简单表型分类。
Intest Res. 2018 Apr;16(2):288-292. doi: 10.5217/ir.2018.16.2.288. Epub 2018 Apr 30.
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HLA-DQ: Celiac disease inflammatory bowel disease.HLA-DQ:乳糜泻与炎症性肠病。
World J Gastroenterol. 2018 Jan 7;24(1):96-103. doi: 10.3748/wjg.v24.i1.96.
9
Endocrine manifestations in celiac disease.乳糜泻的内分泌表现
World J Gastroenterol. 2016 Oct 14;22(38):8472-8479. doi: 10.3748/wjg.v22.i38.8472.

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