Bao Su-Xia, Yuan Xiao-Ling, Yan Lei, Xu Jie
Department of Infectious Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
World J Clin Cases. 2025 May 6;13(13):100735. doi: 10.12998/wjcc.v13.i13.100735.
The introduction of pegaspargase has greatly advanced the treatment of acute lymphoblastic leukemia (ALL). In the literature, only one case of pegaspargase-induced multiple organ failure has been reported, and the patient died due to multiple organ failure.
Herein, we present a rare case of a 40-year-old man with ALL who developed multiple organ failure after treatment with pegaspargase. The patient had two rare phenomena reflecting poor prognosis, including the discrepancy between clinical manifestations and liver function and persistently low alpha-fetoprotein (AFP) levels from subacute liver failure. However, the patient was successfully treated using a multidisciplinary team approach.
This is the first case report of successful treatment of pegaspargase-induced multiple organ failure. The findings emphasize the importance of a multidisciplinary team approach in treating pegaspargase-induced multiple organ failure.
聚乙二醇天冬酰胺酶的引入极大地推动了急性淋巴细胞白血病（ALL）的治疗。在文献中，仅报道过1例聚乙二醇天冬酰胺酶诱发多器官功能衰竭的病例，该患者因多器官功能衰竭死亡。
在此，我们报告1例罕见的40岁ALL男性患者，其在接受聚乙二醇天冬酰胺酶治疗后发生多器官功能衰竭。该患者出现了两种提示预后不良的罕见现象，包括临床表现与肝功能不符以及亚急性肝衰竭导致甲胎蛋白（AFP）水平持续低下。然而，通过多学科团队协作的方法，该患者得到了成功治疗。
这是首例成功治疗聚乙二醇天冬酰胺酶诱发多器官功能衰竭的病例报告。这些发现强调了多学科团队协作方法在治疗聚乙二醇天冬酰胺酶诱发多器官功能衰竭中的重要性。
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