Berimavandi Mina, Abbasi Parvin, Khaledi-Paveh Behnam, Salari Nader
Student Research Committee Kermanshah University of Medical Sciences Kermanshah Iran.
Department of Nursing, School of Nursing and Midwifery Kermanshah University of Medical Sciences Kermanshah Iran.
Health Sci Rep. 2025 May 5;8(5):e70703. doi: 10.1002/hsr2.70703. eCollection 2025 May.
Depression and cardiovascular disease (CVD) by the end of 2030 will be among the major causes of disability worldwide. Meanwhile, medication adherence is an important factor in predicting clinical outcomes in patients with CVD. Further, lack of medication compliance is affected by depression. Thus, this study aimed to explore the relationship between depression and medication adherence among older patients with CVD.
The search was done across eight databases of PubMed/MEDLINE, Google Scholar, Embase, Scopus, APA Psycinfo, CINAHL/ebsco, ProQuest, and Web of Science. For the selection of included studies, there were no constraints regarding publication language. All studies available in each of the databases were searched up to December 9, 2021. Risk of bias assessment was done based on the Joanna Briggs Institute scale. The final result was estimated using a random effects model. The data were analyzed by CMA 2 software.
Seven studies and 10,153 elderly suffering from CVD were identified. Most included studies had reported an inverse association between depression and medication adherence. There was a small effect between depression and medication adherence among these older patients (combined odds ratio 0.603, 95% confidence interval 0.252-1.442). Thus, having depression would reduce medication adherence by 40%.
Depression has a considerable effect on medication adherence among older patients with CVD. Thus, it is suggested that considering the importance of depression and lack of medication adherence in increasing the negative outcomes of this disease in these patients, primary studies be conducted in this regard to achieve conclusive results in subsequent systematic reviews and meta-analyses.
到2030年底，抑郁症和心血管疾病（CVD）将成为全球致残的主要原因。同时，药物依从性是预测CVD患者临床结局的重要因素。此外，抑郁症会影响药物治疗的依从性。因此，本研究旨在探讨老年CVD患者中抑郁症与药物依从性之间的关系。
在PubMed/MEDLINE、谷歌学术、Embase、Scopus、APA Psycinfo、CINAHL/ebsco、ProQuest和科学网这八个数据库中进行检索。对于纳入研究的选择，对出版语言没有限制。检索了每个数据库中截至2021年12月9日的所有可用研究。基于乔安娜·布里格斯研究所的量表进行偏倚风险评估。最终结果使用随机效应模型进行估计。数据由CMA 2软件进行分析。
共纳入7项研究，涉及10153名患有CVD的老年人。大多数纳入研究报告了抑郁症与药物依从性之间存在负相关。在这些老年患者中，抑郁症与药物依从性之间的关联较小（合并比值比为0.603，95%置信区间为0.252 - 1.442）。因此，患有抑郁症会使药物依从性降低40%。
抑郁症对老年CVD患者的药物依从性有相当大的影响。因此，鉴于抑郁症和药物依从性不足在增加这些患者疾病负面结局方面的重要性，建议在这方面开展初步研究，以便在后续的系统评价和荟萃分析中得出确凿的结果。
