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同步放化疗联合度伐利尤单抗治疗后成功取出支架治疗局部晚期非小细胞肺癌伴气道狭窄:三例报告

Successful stent removal after chemoradiotherapy followed by durvalumab for locally advanced non-small cell lung cancer with airway stenosis: A report of three cases.

作者信息

Takigawa Yuki, Sato Ken, Minami Daisuke, Kudo Kenichiro, Matsumoto Shoichiro, Fujiwara Miho, Ichikawa Takeru, Inoue Tomoyoshi, Matsuoka Suzuka, Watanabe Hiromi, Sato Akiko, Shoda Hiroyasu, Ishikawa Nobuhisa, Fujiwara Keiichi, Shibayama Takuo

机构信息

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, 701-1192, Okayama, Japan.

Department of Internal Medicine 4, Kawasaki Medical School, 700-8505, Okayama, Japan.

出版信息

Respir Med Case Rep. 2025 Apr 18;55:102217. doi: 10.1016/j.rmcr.2025.102217. eCollection 2025.

Abstract

Airway stents improve respiratory conditions and Eastern Cooperative Oncology Group Performance Status scores in cases of airway stenosis, as observed in patients with stage III non-small cell lung cancer (NSCLC) who experience prolonged survival after undergoing chemoradiotherapy followed by durvalumab treatment. Herein, we report three cases of severe airway stenosis due to stage III NSCLC in patients who underwent airway stenting and subsequent stent removal after chemoradiotherapy and durvalumab administration. The number of stents removed will likely increase in the future due to the high response rates to molecular drugs and immune checkpoint inhibitors.

摘要

在接受放化疗及度伐利尤单抗治疗后生存期延长的 III 期非小细胞肺癌(NSCLC)患者中观察到,气道支架可改善气道狭窄患者的呼吸状况及东部肿瘤协作组体能状态评分。在此,我们报告 3 例因 III 期 NSCLC 导致严重气道狭窄的患者,他们在接受放化疗及度伐利尤单抗治疗后接受了气道支架置入及后续支架取出术。由于对分子药物和免疫检查点抑制剂的高反应率,未来取出的支架数量可能会增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c08/12051515/15fd3f99a4cc/gr1.jpg

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