Green H S, Triffet T
J Theor Biol. 1985 Jul 7;115(1):43-64. doi: 10.1016/s0022-5193(85)80006-0.
A physically based theory of ionic currents associated with nervous activity is extended to provide a model of electrical activity in the cortex and its immediate neighbourhood. It is shown that the most significant variations of potential in the extracellular fluid are associated with fluctuations in density of calcium and potassium ions. Nervous activity may activate a calcium resonance at the external surface of a neural membrane, which in turn excites a potassium resonance. The resulting variations of electrical potential are sufficient to account for the event related potentials observed in the extracellular fluid. In addition, it is found that periodic variations of potential associated with the potassium resonance may be initiated by metabolic changes in ion concentrations and are in close correspondence with those identified experimentally with the alpha- and beta-rhythms. It is shown how to determine the effective conductance of the neural membrane from ionic theory, with a result comparable to that assumed by Hodgkin & Huxley, under the conditions of the voltage clamp.
一种基于物理原理的与神经活动相关的离子电流理论得到扩展，以提供一个关于皮质及其紧邻区域电活动的模型。结果表明，细胞外液中电位的最显著变化与钙离子和钾离子密度的波动有关。神经活动可能会激活神经膜外表面的钙共振，进而激发钾共振。由此产生的电位变化足以解释在细胞外液中观察到的事件相关电位。此外，发现与钾共振相关的电位周期性变化可能由离子浓度的代谢变化引发，并且与通过实验确定的α波和β波节律密切对应。文中展示了如何从离子理论确定神经膜的有效电导，其结果在电压钳制条件下与霍奇金和赫胥黎所假设的结果相当。
