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在实验性感染期间，他汀类药物不会降低寄生虫负荷。

Statins do not reduce the parasite burden during experimental infection.

作者信息

Razzaq Sarah, Olmo Francisco, Lakshminarayana Suresh B, Ying-Bo Chen, Jayawardhana Shiromani, Rao Srinivasa P S, Kelly John M, A F Francisco

机构信息

Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Department of Parasitology, Faculty of Sciences, University of Granada, Granada, Andalusia, Spain.

出版信息

Antimicrob Agents Chemother. 2025 May 7;69(5):e0013525. doi: 10.1128/aac.00135-25. Epub 2025 Apr 14.

DOI:10.1128/aac.00135-25
PMID:40331859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12057342/
Abstract

Cardiomyopathy is the most common pathology associated with infection. Reports that statins have both cardioprotective and trypanocidal activity have generated interest in their potential as a therapeutic treatment. Using a highly sensitive bioluminescent mouse model, we show that a 5-day treatment with statins has no significant impact on parasite load. The free systemic concentrations fail to reach the level required for potency. Hence, clinical trials to investigate the trypanocidal activity of statins lack experimental justification.

摘要

心肌病是与感染相关的最常见病理状况。有报道称他汀类药物具有心脏保护和杀锥虫活性，这引发了人们对其作为治疗方法潜力的兴趣。我们使用高度敏感的生物发光小鼠模型表明，他汀类药物为期5天的治疗对寄生虫负荷没有显著影响。全身游离浓度未能达到有效所需水平。因此，研究他汀类药物杀锥虫活性的临床试验缺乏实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f3b/12057342/fda23b64606a/aac.00135-25.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f3b/12057342/c46c874fb10a/aac.00135-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f3b/12057342/fda23b64606a/aac.00135-25.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f3b/12057342/c46c874fb10a/aac.00135-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f3b/12057342/fda23b64606a/aac.00135-25.f002.jpg

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本文引用的文献

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Prevalence of clinical forms of Chagas disease: a systematic review and meta-analysis - data from the RAISE study.恰加斯病临床类型的患病率：一项系统评价和荟萃分析——来自RAISE研究的数据。
Lancet Reg Health Am. 2024 Feb 3;30:100681. doi: 10.1016/j.lana.2024.100681. eCollection 2024 Feb.
2
Antiplasmodial, Trypanocidal, and Genotoxicity Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives.新型α,α-二氟苯基乙酰胺-他汀类衍生物的抗疟、抗锥虫及遗传毒性评估
Pharmaceuticals (Basel). 2023 May 24;16(6):782. doi: 10.3390/ph16060782.
3
Statins change the cytokine profile in -infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition.
他汀类药物通过抑制 Rho 相关激酶改变感染的 U937 巨噬细胞和鼠心肌组织中的细胞因子谱。
Front Immunol. 2023 Jan 11;13:1035589. doi: 10.3389/fimmu.2022.1035589. eCollection 2022.
4
Effect of statins on inflammation and cardiac function in patients with chronic Chagas disease: A protocol for pathophysiological studies in a multicenter, placebo-controlled, proof-of-concept phase II trial.他汀类药物对慢性恰加斯病患者炎症和心脏功能的影响：一项多中心、安慰剂对照、概念验证二期临床试验的病理生理学研究方案。
PLoS One. 2023 Jan 13;18(1):e0280335. doi: 10.1371/journal.pone.0280335. eCollection 2023.
5
Statins promote efferocytosis in atherosclerotic plaques.他汀类药物可促进动脉粥样硬化斑块中的吞噬细胞清除作用。
Nat Rev Cardiol. 2022 May;19(5):286. doi: 10.1038/s41569-022-00699-5.
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Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against .基于图像的体外筛选揭示羟甲基硝基呋喃酮对 的抗变形活性。
Int J Mol Sci. 2021 Jun 28;22(13):6930. doi: 10.3390/ijms22136930.
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