Zeng Anqi, Quan Yunyun, Tao Hongxia, Dai Ying, Song Linjiang, Zhao Junning
Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China.
Sichuan Institute for Translational Chinese Medicine, Chengdu 610041, China.
Int J Mol Sci. 2025 Apr 10;26(8):3561. doi: 10.3390/ijms26083561.
Tetrahydrocurcumin (THC), a curcumin derivative, shows potential in oncology and neurology. It regulates NF-κB, reduces inflammation, promotes cancer cell apoptosis, inhibits tumor angiogenesis, and enhances antioxidants, aiding in treating inflammation-related cancers. In neurology, THC's anti-inflammatory and antioxidant properties protect neurons, reduce neuroinflammation, and support autophagy for cellular debris clearance, with its blood-brain barrier penetration offering a neuroprotective edge. Research on THC's therapeutic application must focus on improving delivery and bioavailability and confirming its clinical safety and efficacy.
四氢姜黄素（THC）是一种姜黄素衍生物，在肿瘤学和神经学领域显示出潜力。它调节核因子κB，减轻炎症，促进癌细胞凋亡，抑制肿瘤血管生成，并增强抗氧化剂，有助于治疗与炎症相关的癌症。在神经学方面，THC的抗炎和抗氧化特性可保护神经元，减轻神经炎症，并支持自噬以清除细胞碎片，其对血脑屏障的穿透性赋予了神经保护优势。关于THC治疗应用的研究必须集中在改善递送和生物利用度以及确认其临床安全性和有效性上。
