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四氢姜黄素通过抑制小胶质细胞中的JAK/STAT和Nrf2/HO-1信号通路对脂多糖诱导的炎症产生抑制作用。

Suppressive Effect of Tetrahydrocurcumin on Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells.

作者信息

Lin Hui-Wen, Chen Tzu-Chun, Yeh Jui-Hsuan, Tsou Shang-Chun, Wang Inga, Shen Ting-Jing, Chuang Chen-Ju, Chang Yuan-Yen

机构信息

Department of Optometry, Asia University, Taichung 41354, Taiwan.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.

出版信息

Oxid Med Cell Longev. 2022 Mar 11;2022:4978556. doi: 10.1155/2022/4978556. eCollection 2022.

DOI:10.1155/2022/4978556
PMID:35308172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8933080/
Abstract

Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat () lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced LPS-induced mortality and the production of inflammatory mediators IL-6, TNF-, MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNFB cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in LPS-stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF-B activation and inducing Nrf2-mediated HO-1 expression.

摘要

脑炎症是神经退行性疾病的一个病理特征，表现为小胶质细胞活性升高和炎症因子水平增加。本研究旨在评估姜黄素的主要氢化代谢产物四氢姜黄素（THC）的抗炎反应，将其应用于治疗脂多糖（LPS）刺激的BV2小胶质细胞。THC降低了LPS诱导的死亡率以及炎症介质白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、巨噬细胞炎性蛋白-2（MIP-2）、干扰素诱导蛋白10（IP-10）和亚硝酸盐的产生。进一步研究表明，THC与JAK/STAT信号抑制剂协同降低了这些炎性细胞因子。THC还增强了Nrf2/HO-1信号转导，从而抑制诱导型一氧化氮合酶（iNOS）/环氧化酶-2（COX-2）/磷酸化核因子κB（pNFB）级联反应。此外，HO-1抑制剂Snpp的存在增加了IP-10、IL-6和亚硝酸盐的水平，但THC处理降低了LPS刺激的BV2细胞中的这些炎症因子水平。总之，我们证明THC通过抑制STAT1/3依赖性核因子κB激活和诱导Nrf2介导的HO-1表达，在LPS诱导的脑小胶质细胞炎症中表现出抗炎活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/feedc25f600d/OMCL2022-4978556.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/e7b5a87b2094/OMCL2022-4978556.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/feedc25f600d/OMCL2022-4978556.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/6eefea267d8b/OMCL2022-4978556.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/be0971819dbe/OMCL2022-4978556.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/4041333ad9a2/OMCL2022-4978556.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/06f9b77d56f8/OMCL2022-4978556.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/5a78f810feda/OMCL2022-4978556.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/98993cc2b500/OMCL2022-4978556.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/e7b5a87b2094/OMCL2022-4978556.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47ed/8933080/feedc25f600d/OMCL2022-4978556.008.jpg

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2
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Biomed Pharmacother. 2021 Jul;139:111651. doi: 10.1016/j.biopha.2021.111651. Epub 2021 May 8.
3
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Int J Mol Sci. 2024 Oct 19;25(20):11266. doi: 10.3390/ijms252011266.
4
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4
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Evid Based Complement Alternat Med. 2020 Dec 22;2020:8856135. doi: 10.1155/2020/8856135. eCollection 2020.
5
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6
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