Yang Lin, Wei Wenjie, Yuan Xun, Guo Ergang, Peng Ping, Wang Jing, Sun Wei
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Int J Mol Sci. 2025 Apr 16;26(8):3743. doi: 10.3390/ijms26083743.
Radiotherapy is a standard cancer treatment that involves the induction of DNA damage. DNA damage repair (DDR) pathways maintain genomic integrity and make tumors resistant to radiotherapy and certain chemotherapies. In turn, DDR dysfunction results in cumulative DNA damage, leading to increased sensitivity for antitumor treatment. Moreover, radiotherapy has been shown to trigger antitumor immunity. Currently, immunotherapy has become a new and widely used standard strategy for treating a broad spectrum of tumor types. Notably, recent studies have demonstrated that DDR pathways play important roles in driving the response to immunotherapy. Herein, we review and discuss how DDR affects antitumor immunity induced by radiotherapy. Furthermore, we summarize the development of strategies for combining DDR inhibitors with radiotherapy and/or immunotherapy to enhance their efficacy against cancers.
放射治疗是一种标准的癌症治疗方法，涉及诱导DNA损伤。DNA损伤修复（DDR）途径维持基因组完整性，并使肿瘤对放射治疗和某些化疗产生抗性。反过来，DDR功能障碍会导致累积的DNA损伤，从而增加对抗肿瘤治疗的敏感性。此外，放射治疗已被证明可触发抗肿瘤免疫。目前，免疫疗法已成为治疗多种肿瘤类型的一种新的广泛应用的标准策略。值得注意的是，最近的研究表明，DDR途径在驱动免疫治疗反应中起重要作用。在此，我们回顾并讨论DDR如何影响放射治疗诱导的抗肿瘤免疫。此外，我们总结了将DDR抑制剂与放射治疗和/或免疫疗法联合使用以增强其抗癌疗效的策略的发展情况。
