Harbi Hanin, Lundby Carina, Jensen Peter Bjødstrup, Larsen Søren Post, Rørbæk Linda Grouleff, Ravn-Nielsen Lene Vestergaard, Ryg Jesper, Reilev Mette, Edwards Kasper, Pottegård Anton
Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Hospital Pharmacy Funen, Odense University Hospital, Odense, Denmark.
Eur Geriatr Med. 2025 May 7. doi: 10.1007/s41999-025-01210-2.
Patients in temporary stays are typically older individuals with frailty and multimorbidity. However, limited knowledge exists about their medication use. This study aimed to describe prescription drug use among patients in temporary stays in Denmark.
We conducted a drug utilisation study on 11,424 patients in public healthcare-operated temporary stay units across 14 Danish municipalities between 2016 and 2023 (median age 81 years; 54% women). Prescription data were sourced from the Danish National Prescription Registry.
Patients used a median of six drug classes (interquartile range [IQR] 4-10) in the four months before moving into a temporary stay facility; 68% used ≥ 5 drug classes, and 26% used ≥ 10. The most commonly used drug classes were paracetamol (49%), statins (30%), and proton pump inhibitors (29%). The monthly rate of new drug use increased from 23/100 patients six months before move-in to a peak of 262/100 patients in the first month after move-in, driven primarily by laxatives, analgesics, and antibiotics. High-risk drug use increased from 70 to 83% following move-in, with 49% of patients initiating at least one new high-risk drug, most commonly opioids (28%), potassium (17%), and anticoagulants and platelet inhibitors (15%). General practitioners initiated 60-70% of treatments and maintained 80-90%. Hospital physician prescriptions increased around move-in, peaking at 55% for initiation and 25% for maintenance in the first month after move-in.
Patients in temporary stays in Denmark demonstrate high medication use, including high-risk drugs, with a notable increase in treatment initiations around the time of move-in.
临时住院患者通常是体弱多病的老年人。然而,我们对他们的用药情况了解有限。本研究旨在描述丹麦临时住院患者的处方药使用情况。
我们对2016年至2023年期间丹麦14个市政当局公共医疗运营的临时住院单元中的11424名患者进行了药物利用研究(中位年龄81岁;54%为女性)。处方数据来自丹麦国家处方登记处。
患者在入住临时住院设施前四个月使用的药物类别中位数为6种(四分位间距[IQR]为4 - 10);68%的患者使用≥5种药物类别,26%的患者使用≥10种。最常用的药物类别是对乙酰氨基酚(49%)、他汀类药物(30%)和质子泵抑制剂(29%)。新药使用月率从入住前六个月的每100名患者23种增加到入住后第一个月的每100名患者262种的峰值,主要由泻药、镇痛药和抗生素推动。入住后高风险药物使用从70%增加到83%,49%的患者开始使用至少一种新的高风险药物,最常见的是阿片类药物(28%)、钾(17%)以及抗凝剂和血小板抑制剂(15%)。全科医生启动了60 - 70%的治疗并维持了80 - 90%的治疗。医院医生的处方在入住前后增加,在入住后第一个月启动处方的比例达到峰值55%,维持处方的比例达到25%。
丹麦临时住院患者用药量大,包括高风险药物,且在入住前后治疗启动量显著增加。