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基于疫苗：1型糖尿病的一种有前景的策略。

-Based Vaccine: A Promising Strategy for Type 1 Diabetes.

作者信息

Singer Mahmoud, Kandeel Fouad, Husseiny Mohamed I

机构信息

Department of Radiological Sciences, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.

Department of Translational Research and Cellular Therapeutics, Artur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

出版信息

Vaccines (Basel). 2025 Apr 14;13(4):405. doi: 10.3390/vaccines13040405.

DOI:10.3390/vaccines13040405
PMID:40333284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12031388/
Abstract

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the progressive destruction of insulin-producing β-cells in the pancreas. Currently, no therapy exists to halt or cure T1D. Vaccination with diabetic autoantigens may offer protection against T1D development. Genetically modified, attenuated utilizing the -Pathogenicity Island 2 (SPI2)-encoded Type Three Secretion System (T3SS) can elicit robust immune responses, making it an attractive vaccine platform. Using SPI2-T3SS to deliver an autoantigen alongside immunomodulators and anti-CD3 antibodies induces antigen-specific regulatory T-cells. Our preclinical studies demonstrated the efficacy of a -based vaccine in both preventing and reversing autoimmune diabetes in non-obese diabetic (NOD) mice while also exploring its genetic modifications, underlying mechanisms, and delivery strategies. This review evaluates the advantages of an oral T1D vaccine employing live, attenuated for autoantigen delivery. We also discuss future directions for advancing this strategy in the treatment of other autoimmune diseases.

摘要

1型糖尿病（T1D）是一种慢性自身免疫性疾病，其特征是胰腺中产生胰岛素的β细胞逐渐被破坏。目前，尚无治疗方法能够阻止或治愈T1D。用糖尿病自身抗原进行疫苗接种可能会提供针对T1D发展的保护作用。利用2型致病岛（SPI2）编码的三型分泌系统（T3SS）进行基因改造减毒的[细菌名称未给出]能够引发强烈的免疫反应，使其成为一个有吸引力的疫苗平台。使用SPI2-T3SS与免疫调节剂和抗CD3抗体一起递送自身抗原可诱导抗原特异性调节性T细胞。我们的临床前研究证明了一种基于[细菌名称未给出]的疫苗在预防和逆转非肥胖糖尿病（NOD）小鼠自身免疫性糖尿病方面的疗效，同时还探索了其基因改造、潜在机制和递送策略。本综述评估了使用减毒活[细菌名称未给出]进行自身抗原递送的口服T1D疫苗的优势。我们还讨论了推进该策略用于治疗其他自身免疫性疾病的未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/33c8a49222e8/vaccines-13-00405-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/31c31b4ab3d1/vaccines-13-00405-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/469c779050d3/vaccines-13-00405-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/33c8a49222e8/vaccines-13-00405-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/31c31b4ab3d1/vaccines-13-00405-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/469c779050d3/vaccines-13-00405-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d6/12031388/33c8a49222e8/vaccines-13-00405-g003.jpg

相似文献

[1]
-Based Vaccine: A Promising Strategy for Type 1 Diabetes.

Vaccines (Basel). 2025-4-14

[2]
An oral vaccine for type 1 diabetes based on live attenuated Salmonella.

Vaccine. 2014-3-12

[3]
Factors affecting Salmonella-based combination immunotherapy for prevention of type 1 diabetes in non-obese diabetic mice.

Vaccine. 2018-11-8

[4]
Reversal of New Onset Type 1 Diabetes by Oral -Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice.

Front Immunol. 2019-2-26

[5]
Tracking of an Oral -Based Vaccine for Type 1 Diabetes in Non-obese Diabetic Mice.

Front Immunol. 2020

[6]
Oral Mutant as a Carrier for a -Based Vaccine for Prevention and Reversal of Type 1 Diabetes.

Front Immunol. 2021

[7]
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.

Sci Rep. 2017-2-13

[8]
Proteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas.

J Proteomics. 2023-1-6

[9]
Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes.

PLoS One. 2019-3-25

[10]
Mechanism of Action of Oral -Based Vaccine to Prevent and Reverse Type 1 Diabetes in NOD Mice.

Vaccines (Basel). 2024-3-6

本文引用的文献

[1]
Regulatory T-cells: The Face-off of the Immune Balance.

Front Biosci (Landmark Ed). 2024-11-8

[2]
Immunological Considerations for the Development of an Effective Herpes Vaccine.

Microorganisms. 2024-9-6

[3]
Antigen-specific T cell responses in autoimmune diabetes.

Front Immunol. 2024

[4]
Teplizumab's immunomodulatory effects on pancreatic β-cell function in type 1 diabetes mellitus.

Clin Diabetes Endocrinol. 2024-8-10

[5]
Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes.

Mol Metab. 2024-10

[6]
Genetic engineering of spp. for novel vaccine strategies and therapeutics.

EcoSal Plus. 2024-12-12

[7]
INfluenza VaccInation To mitigate typE 1 Diabetes (INVITED): a study protocol for a randomised, double-blind, placebo-controlled clinical trial in children and adolescents with recent-onset type 1 diabetes.

BMJ Open. 2024-7-1

[8]
First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers.

BMC Med. 2024-6-21

[9]
BCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8 T Cells in Patients with Type 1 Diabetes in Ghana.

Vaccines (Basel). 2024-4-24

[10]
Reversal of diabetes by an oral Salmonella-based vaccine in acute and progressive diabetes in NOD mice.

PLoS One. 2024

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