在大鼠腹腔注射乙醇后不久，乙醇会使血浆血管加压素增加。

Ethanol increases plasma vasopressin shortly after intraperitoneal injection in rats.

作者信息

Colbern D L, ten Haaf J, Tabakoff B, van Wimersma Greidanus T B

出版信息

Life Sci. 1985 Sep 16;37(11):1029-32. doi: 10.1016/0024-3205(85)90592-2.

Abstract

In rats, ethanol has generally been thought to inhibit vasopressin (VP) release into the peripheral circulation; however, the primary evidence for this conclusion has been indirect. Radioimmunoassay was used to measure VP in the plasma of rats decapitated 5 or 60 min after intraperitoneal injection of ethanol (2.0 g/kg). Confirming the popular notion that ethanol inhibits VP release, VP levels were decreased 60 min after treatment. But radioimmunoassay techniques also revealed that VP release is markedly stimulated shortly after an injection of ethanol.

摘要

在大鼠中，乙醇通常被认为会抑制血管加压素（VP）释放进入外周循环；然而，这一结论的主要证据一直是间接的。采用放射免疫分析法测量腹腔注射乙醇（2.0克/千克）后5分钟或60分钟断头的大鼠血浆中的VP。证实了乙醇抑制VP释放这一普遍观点，治疗后60分钟VP水平降低。但放射免疫分析技术也显示，注射乙醇后不久VP释放会受到显著刺激。