Šubarić Domagoj, Rastija Vesna, Karnaš Babić Maja, Agić Dejan, Majić Ivana
Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, Vladimira Preloga 1, HR-31000 Osijek, Croatia.
Molecules. 2025 Apr 8;30(8):1662. doi: 10.3390/molecules30081662.
Although the present use of pesticides in plant protection has limited the occurrence and development of plant diseases and pests, resistance to pesticides and their environmental and health hazards indicates an urgent need for new active ingredients in plant protection products. Recently synthesized coumarin-1,2,4-triazole hybrid compounds have been proven effective against plant pathogenic fungi and safe for soil-beneficial bacteria. , the common fruit fly, has been used as a model organism for scientific research. Additionally, it is considered a pest since it damages fruits and serves as a carrier for various plant diseases. On the contrary, is a beneficial true bug that biologically controls harmful arthropods in agricultural production. In the present study, we performed an adulticidal bioassay against and using coumarin-1,2,4-triazole hybrids. Quantitative structure-activity relationship studies (QSARs) and in silico ecotoxicity evaluation elucidated the structural features underlying the compounds' insecticidal activity. The derivative of 4-methylcoumarin-1,2,4-triazole with a 3-bromophenyl group showed great insecticidal potential. A molecular docking study indicated that the most active compound probably binds to glutamate-gated chloride channels.
尽管目前在植物保护中使用农药限制了植物病虫害的发生和发展，但对农药的抗性及其对环境和健康的危害表明，迫切需要植物保护产品中的新型活性成分。最近合成的香豆素-1,2,4-三唑杂化化合物已被证明对植物病原真菌有效，且对土壤有益细菌安全。果蝇已被用作科学研究的模式生物。此外，由于它会损害果实并充当各种植物病害的载体，所以被视为害虫。相反，某虫蝽是一种有益的真蝽，可在农业生产中对有害节肢动物进行生物防治。在本研究中，我们使用香豆素-1,2,4-三唑杂化物对果蝇和某虫蝽进行了成虫icidal生物测定。定量构效关系研究（QSARs）和计算机生态毒性评估阐明了化合物杀虫活性的结构特征。具有3-溴苯基的4-甲基香豆素-1,2,4-三唑衍生物显示出巨大的杀虫潜力。分子对接研究表明，活性最高的化合物可能与谷氨酸门控氯离子通道结合。
原文中“adulticidal bioassay”的“adulticidal”疑似拼写错误，可能是“adulticidal”，推测意思是“成虫杀灭生物测定”，这里按推测进行了翻译，你可根据实际情况调整。
