Matias Kételin Vitória, Gonçalves Valeria de Cassia, Scorza Fulvio Alexandre, Finsterer Josef, Ciconelli Rozana Mesquita, Scorza Carla Alessandra
Disciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, Brazil.
Departamento de Pesquisa da BP, A Beneficência Portuguesa de São Paulo, São Paulo 01323-001, SP, Brazil.
Molecules. 2025 Apr 8;30(8):1672. doi: 10.3390/molecules30081672.
Parkinson's disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory dysfunction, and pain. Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis is a natural bee-derived product, rich in bioactive compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, which holds potential in PD due to its multitarget and multipathway actions, addressing various underlying mechanisms of non-motor symptom diseases. Preclinical and clinical studies suggest that propolis may influence key pathological mechanisms in PD's non-motor symptoms. Evidence points to its potential benefits in improving cognition, mood disorders, gastrointestinal health, and alleviating cardiovascular and sleep-related issues. Although research on propolis in non-motor symptoms of PD remains scarce, findings from related conditions suggest its ability to influence mechanisms associated with these symptoms. This review underscores the underexplored therapeutic potential of propolis in non-motor symptoms of PD, drawing on existing evidence and advocating for further research to fully assess its role in addressing these symptoms and improving patient outcomes.
帕金森病（PD）是一种复杂的神经退行性疾病，伴有使人衰弱的非运动症状，包括胃肠功能障碍、心血管异常、情绪和焦虑障碍、认知衰退、睡眠障碍、呼吸功能障碍和疼痛。尽管这些症状对生活质量有重大影响，但往往未得到充分治疗。蜂胶是一种天然的蜜蜂衍生产品，富含具有抗炎、抗氧化、免疫调节和神经保护特性的生物活性化合物，由于其多靶点和多途径作用，针对非运动症状疾病的各种潜在机制，在帕金森病中具有应用潜力。临床前和临床研究表明，蜂胶可能会影响帕金森病非运动症状的关键病理机制。有证据表明，它在改善认知、情绪障碍、胃肠健康以及缓解心血管和睡眠相关问题方面具有潜在益处。尽管关于蜂胶在帕金森病非运动症状方面的研究仍然很少，但相关病症的研究结果表明其能够影响与这些症状相关的机制。本综述强调了蜂胶在帕金森病非运动症状方面尚未得到充分探索的治疗潜力，借鉴现有证据并倡导进一步研究，以全面评估其在解决这些症状和改善患者预后方面的作用。
