甘油三酯-葡萄糖指数与 142184 名中国成年人乳腺癌的相关性：REACTION 研究的结果。
Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study.
机构信息
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Front Endocrinol (Lausanne). 2024 Jun 6;15:1321622. doi: 10.3389/fendo.2024.1321622. eCollection 2024.
BACKGROUND
The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.
METHODS
This cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.
RESULTS
Multivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19-2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13-17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09-1.68), 1.27 (1.05-1.54), 1.26 (1.05-1.52), and 1.32 (1.08-1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44-3.87).
CONCLUSION
The TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.
背景
甘油三酯-葡萄糖（TyG）指数与乳腺癌风险增加相关。然而，这种关联在中国人群中尚不清楚。本研究旨在探讨 TyG 指数是否与中国女性的乳腺癌发病风险相关。
方法
本横断面研究纳入了来自中国糖尿病风险评估研究（REACTION）的 142184 名女性，该研究于 2011 年至 2012 年期间在中国大陆 25 个中心招募了 40 岁及以上的成年人。TyG 指数根据公式：Ln（空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2）计算。多变量调整的 logistic 回归模型用于评估 TyG 指数与乳腺癌之间的关联的比值比（ORs）和 95%置信区间（CIs）。
结果
多变量调整的 logistic 回归分析显示，与 TyG 指数最低四分位相比，TyG 指数最高四分位与乳腺癌发病风险增加显著相关，OR（95%CI）为 1.61（1.19-2.17）。在分层分析中，TyG 指数每增加 1 SD 与乳腺癌发病风险的关联在月经初潮年龄为 13-17 岁、绝经后、有母乳喂养史和生育 2-4 个孩子的个体中更为明显，ORs（95%CI）分别为 1.35（1.09-1.68）、1.27（1.05-1.54）、1.26（1.05-1.52）和 1.32（1.08-1.62）。此外，在无明显胰岛素抵抗（稳态模型评估-胰岛素抵抗[HOMA-IR]≥2.5）、高血糖和血脂异常的个体中，TyG 指数每增加 1 SD，乳腺癌风险增加 1.36 倍，OR（95%CI）为 2.36（1.44-3.87）。
结论
TyG 指数与中国中老年女性的乳腺癌发病风险显著相关。
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