Zhang Lingbo, Chen Muhua, Wang Weihao, Luo Zhijie, Zheng Yuhui
Department of Anesthesiology, Xiangya Hospital Central South University, Changsha 410008, China.
Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China.
Molecules. 2025 Apr 16;30(8):1782. doi: 10.3390/molecules30081782.
We report the design and biological evaluation of a nanoplatform featuring controllable aggregation-induced emission (AIE) behavior. The free rotation of benzene rings (4-(1,2,2-triphenylvinyl) benzaldehyde) largely suppresses fluorescence in the pure organic phase. However, water-induced molecular aggregation enhances the fluorescence signal. The delivery system follows the membrane-cytoplasm-nucleus route and it leads to apoptosis in two cancer cells (U937 cells and Hela cells). The AIE moiety accumulates in the cytoplasm, emitting a bright-blue signal, but the anticancer drug doxorubicin selectively targets the nucleus with unique red emission. The current noninvasive method with DOX-triggered apoptosis holds promise for tumor diagnosis and real-time imaging.
我们报告了一种具有可控聚集诱导发光（AIE）行为的纳米平台的设计及生物学评估。苯环（4-(1,2,2-三苯基乙烯基)苯甲醛）的自由旋转在纯有机相中极大地抑制了荧光。然而，水诱导的分子聚集增强了荧光信号。该递送系统遵循膜-细胞质-细胞核途径，并导致两种癌细胞（U937细胞和Hela细胞）凋亡。AIE部分在细胞质中积累，发出亮蓝色信号，而抗癌药物阿霉素则以独特的红色发射选择性地靶向细胞核。目前这种由阿霉素触发凋亡的非侵入性方法在肿瘤诊断和实时成像方面具有前景。
