Wang Jinfeng, Li Jingjing, Huo Jing, Zhao Yaxi, Liu Kangkang, Wang Huijie, Cao Xu
Department of Surgery, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China.
Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China.
PLoS One. 2025 May 7;20(5):e0322789. doi: 10.1371/journal.pone.0322789. eCollection 2025.
Fibrinogen has been associated with a variety of malignancies, including colorectal cancer (CRC). However, there is no study on the relationship between fibrinogen and CRC specifically in the Chinese population. The objective of this study was to analyze the relationship between fibrinogen and CRC in the Chinese population. This study included consecutive inpatients undergoing colonoscopies (April 2015‒June 2022). A total of 3,595 individuals, comprising 468 CRCs and 3,127 controls, were included. Logistic regression models and restricted cubic spline analysis were employed to assess the association between fibrinogen and CRC. When fibrinogen levels were divided into quartiles, the ORs for CRC in Q2, Q3, and Q4 compared to Q1 were 2.72 (95% CI: 1.57-4.74), 4.84 (95% CI: 2.84-8.25), and 9.55 (95% CI: 5.55-16.43), respectively. Restricted cubic spline analysis identified a non-linear association between fibrinogen levels and CRC risk with a threshold of 3.794 (95% CI: 3.747-3.841) g/L. Below this threshold, the CRC risk significantly increased (OR 5.944, 95% CI 4.084-8.65, P < 0.001). These findings may offer new insights for the diagnosis and management of CRC.
纤维蛋白原与多种恶性肿瘤有关，包括结直肠癌（CRC）。然而，专门针对中国人群的纤维蛋白原与结直肠癌之间关系的研究尚无。本研究的目的是分析中国人群中纤维蛋白原与结直肠癌之间的关系。本研究纳入了连续接受结肠镜检查的住院患者（2015年4月至2022年6月）。共纳入3595人，包括468例结直肠癌患者和3127例对照。采用逻辑回归模型和受限立方样条分析来评估纤维蛋白原与结直肠癌之间的关联。当将纤维蛋白原水平分为四分位数时，与第一四分位数相比，第二、第三和第四四分位数中结直肠癌的比值比分别为2.72（95%置信区间：1.57 - 4.74）、4.84（95%置信区间：2.84 - 8.25）和9.55（95%置信区间：5.55 - 16.43）。受限立方样条分析确定纤维蛋白原水平与结直肠癌风险之间存在非线性关联，阈值为3.794（95%置信区间：3.747 - 3.841）g/L。低于该阈值时，结直肠癌风险显著增加（比值比5.944，95%置信区间4.084 - 8.65，P < 0.001）。这些发现可能为结直肠癌的诊断和管理提供新的见解。
