Papila Kundaktepe Berrin, Papila Cigdem
Department of General Surgery, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
World J Surg Oncol. 2021 Mar 11;19(1):69. doi: 10.1186/s12957-021-02180-y.
Several aspects of the correlation between colon cancer and hemostatic markers are still unknown to many researchers in the field. In this study, we evaluated the association, if any, of preoperative platelet (PLT) counts and plasma fibrinogen levels with postoperative lymph node involvement and venous invasion in colon cancer patients.
This study retrospectively included eighty patients with colon cancer (mean age 58.09 years; 37% female 63% male).
Patients with negative lymph nodes and venous invasion showed a significantly lower PLT count and higher fibrinogen level than their counterparts, i.e., patients with positive lymph nodes (p<0.001, all of them) and venous invasion (p<0.001, all of them). The results also showed a positive association of PLT counts and fibrinogen levels with lymphatic invasion (r=0.670, p<0.001 and r=0.639, p<0.001, respectively) and a positive association of PLT counts and fibrinogen levels with venous invasion (r=0.3988, p<0.001 and r=0.5268, p<0.001, respectively). According to the results of the ROC curve analysis, when the PLT count cutoff was 290/mm, the sensitivity and specificity were 82% and 86.67%, respectively (AUC = 0.8840, p<0.0001, 95% CI 0.8084-0.9596). When the fibrinogen level cutoff was 310.0 mg/dL, the sensitivity and specificity were 72% and 96.67%, respectively (AUC 0.8790, p <0.0001, 95% CI 0.8067-0.9513).
The preoperative PLT count and plasma fibrinogen level may be considered key markers to monitor postoperative lymph node involvement and venous invasion in colon cancer patients.
该领域的许多研究人员对结肠癌与止血标志物之间相关性的几个方面仍不了解。在本研究中，我们评估了结肠癌患者术前血小板（PLT）计数和血浆纤维蛋白原水平与术后淋巴结受累及静脉侵犯之间是否存在关联。
本研究回顾性纳入了80例结肠癌患者（平均年龄58.09岁；女性37%，男性63%）。
淋巴结和静脉侵犯为阴性的患者，其PLT计数显著低于淋巴结阳性（所有p<0.001）和静脉侵犯阳性（所有p<0.001）的患者，而纤维蛋白原水平则更高。结果还显示，PLT计数和纤维蛋白原水平与淋巴侵犯呈正相关（r分别为0.670，p<0.001和0.639，p<0.001），与静脉侵犯也呈正相关（r分别为0.3988，p<0.001和0.5268，p<0.001）。根据ROC曲线分析结果，当PLT计数临界值为290/mm时，敏感性和特异性分别为82%和86.67%（AUC = 0.8840，p<0.0001，95%CI 0.8084 - 0.9596）。当纤维蛋白原水平临界值为310.0 mg/dL时，敏感性和特异性分别为72%和96.67%（AUC 0.8790，p <0.0001，95%CI 0.8067 - 0.9513）。
术前PLT计数和血浆纤维蛋白原水平可被视为监测结肠癌患者术后淋巴结受累及静脉侵犯的关键标志物。
