Zhu Aoxue, Xie Huiling, Wei Juan, Wang Mei, Huang Tianrong, Mao Huina
Department of Nursing, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; School of Nursing, Southern Medical University, Guangzhou 510515, China.
Department of Geriatric Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510505, China.
Geriatr Nurs. 2025 May-Jun;63:567-573. doi: 10.1016/j.gerinurse.2025.04.004. Epub 2025 May 6.
Parkinson's disease is a neurodegenerative disorder causing physical and psychological challenges. Stigma exacerbates negative emotions, resulting in anxiety and depression, as well as undermining self-perception and social participation. Health literacy aids in disease management, and family function plays a crucial supportive role. However, the interplay between these variables remains underexplored.
To examine the chain mediating effects of health literacy and family function between stigma and negative emotions in patients with Parkinson's disease.
This study adopted a cross-sectional design, recruiting eligible patients from a tertiary hospital in Guangzhou, China. A total of 245 participants completed questionnaires on stigma, health literacy, family function and negative emotions. Statistical analyses were performed using Spearman's correlation and mediation effect analysis.
Negative emotions were positively correlated with stigma (β = 0.584) and inversely associated with health literacy (β = -0.258) and family function (β = -0.144). Mediation effect analysis showed that the mediating effects of health literacy, family function, and their combined effects on the relationship between stigma and negative emotions were 0.033, 0.020, and 0.008, respectively, accounting for 8.89%, 5.39%, and 2.16% of the total effect.
Stigma in patients with Parkinson's disease not only directly affects negative emotions but also indirectly influences them through health literacy and family function.
帕金森病是一种神经退行性疾病，会带来身体和心理方面的挑战。污名化加剧负面情绪，导致焦虑和抑郁，还会损害自我认知和社会参与。健康素养有助于疾病管理，家庭功能起着至关重要的支持作用。然而，这些变量之间的相互作用仍未得到充分探索。
探讨帕金森病患者污名与负面情绪之间健康素养和家庭功能的链式中介作用。
本研究采用横断面设计，从中国广州一家三级医院招募符合条件的患者。共有245名参与者完成了关于污名、健康素养、家庭功能和负面情绪的问卷调查。采用Spearman相关性分析和中介效应分析进行统计分析。
负面情绪与污名呈正相关（β = 0.584），与健康素养呈负相关（β = -0.258），与家庭功能呈负相关（β = -0.144）。中介效应分析表明，健康素养、家庭功能及其联合作用对污名与负面情绪关系的中介效应分别为0.033、0.020和0.008，分别占总效应的8.89%、5.39%和2.16%。
帕金森病患者的污名不仅直接影响负面情绪，还通过健康素养和家庭功能间接影响负面情绪。
