Menoncin Bruna Leticia Vessoni, Bloembergen Wendy, Jones Nathan, Hoxie Adam, Finkelman Matthew, Zandona Andrea Ferreira
Department of Comprehensive Care, Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
GreenMark Biomedical Inc., Ann Arbor, Michigan, USA.
Int Dent J. 2025 May 6;75(4):100764. doi: 10.1016/j.identj.2025.02.003.
This in vitro study aimed to compare the agreement of a starch-based nanoparticle fluorescence rinse (FR) (LumiCare™ Caries Detection Rinse, GreenMark Biomedical Inc.) in the assessment of caries activity of initial smooth surface carious lesions with the International Caries Classification and Management System (ICCMS) Lesion Activity Assessment.
A convenience sample of permanent extracted human teeth (N = 57) were scored by visual assessment (VA) using the ICCMS activity criteria by 2 calibrated examiners. VA categories included: sound, inactive and active. For fluorescence assessment (FA), each tooth was fully immersed in FR for 30 seconds, rinsed with water for 10 seconds, compressed air dried and examined under an orange filter while illuminating with a curing light. Fluorescence was assessed as no fluorescence or fluorescence. Both VA and FA were repeated after at least 24 hours and Kappa was calculated for inter- and intra-examiner agreement.
Based on VA, 12 teeth (21%) were classified into the active category, while 45 teeth (79%) were classified into the sound (n = 20) or inactive (n = 25) categories. When combining the latter 2 categories, VA and FA's classifications were concordant in 100% of cases (all 12 teeth in VA's active category exhibited fluorescence, and all 45 teeth in VA's sound/inactive category did not exhibit fluorescence according to FA; Kappa = 1).
FA with FR demonstrated perfect agreement with VA using ICCMS when comparing active versus inactive and/or sound surfaces suggesting it has potential as an objective indicator of caries activity.
A fluorescence rinse could improve clinical detection of smooth surface caries activity and could easily be integrated as part of the dental hygiene appointment.
本体外研究旨在比较基于淀粉的纳米颗粒荧光漱口水（FR）（LumiCare™龋齿检测漱口水，GreenMark Biomedical Inc.）与国际龋病分类和管理系统（ICCMS）病变活动评估在评估初始平滑面龋损龋病活动方面的一致性。
通过便利抽样选取57颗拔除的恒牙，由2名经过校准的检查者使用ICCMS活动标准进行视觉评估（VA）评分。VA类别包括：健康、静止和活跃。对于荧光评估（FA），将每颗牙齿完全浸入FR中30秒，用水冲洗10秒，用压缩空气吹干，然后在橙色滤光片下用固化灯照射进行检查。荧光评估为无荧光或有荧光。VA和FA在至少24小时后重复进行，并计算检查者间和检查者内一致性的Kappa值。
基于VA，12颗牙齿（21%）被分类为活跃类别，而45颗牙齿（79%）被分类为健康（n = 20）或静止（n = 25）类别。当合并后两类时，VA和FA的分类在100%的病例中一致（VA活跃类别中的所有12颗牙齿均显示荧光，而VA健康/静止类别中的所有45颗牙齿根据FA均未显示荧光；Kappa = 1）。
在比较活跃与静止和/或健康表面时，使用FR进行的FA与使用ICCMS的VA显示出完美的一致性，表明它有潜力作为龋病活动的客观指标。
荧光漱口水可改善平滑面龋病活动的临床检测，并且可以很容易地作为口腔卫生检查的一部分。
