Bertollo Amanda Gollo, Capitanio Milene Zanella, Schuh Laysa Anacleto, Pradella Nandara, Ignácio Zuleide Maria
Federal University of Santa Catarina, Brazil.
Community University of Chapecó Region, SC, Brazil.
Behav Brain Res. 2025 Jul 26;490:115630. doi: 10.1016/j.bbr.2025.115630. Epub 2025 May 5.
Major depressive disorder (MDD) is prevalent worldwide and impacts the health and quality of life of millions of people. MDD is a condition influenced by a complex interplay of genetic, psychological and environmental factors. This narrative review examines the roles of stress vulnerability, resilience, and lifestyle habits in shaping the risk of depression, emphasizing holistic approaches that address both biological and environmental factors in mental health management. Vulnerability to stress, influenced by factors such as childhood adversity and personality traits such as neuroticism, increases the probability of MDD. On the other hand, resilience acts as a protective mechanism, reducing stress reactivity and supporting mental health. The main findings suggest that healthy lifestyle habits, including consistent sleep patterns, a balanced diet and regular exercise, play significant roles in increasing resilience and preventing depressive symptoms. Interventions to build resilience, such as emotional skills training and promoting a growth mindset, have been proven effective in reducing depressive symptoms. Overall, the findings suggest that lifestyle modifications combined with psychological strategies to build resilience can significantly reduce depressive disorders. This study advocates for personalized therapeutic strategies that consider the multifactorial nature of depressive disorders, integrating psychological and lifestyle interventions to enhance resilience and mental health.
重度抑郁症(MDD)在全球范围内普遍存在,影响着数百万人的健康和生活质量。MDD是一种受遗传、心理和环境因素复杂相互作用影响的疾病。这篇叙述性综述探讨了应激易感性、复原力和生活方式习惯在塑造抑郁症风险中的作用,强调了在心理健康管理中应对生物和环境因素的整体方法。受童年逆境等因素以及神经质等人格特质影响的应激易感性会增加患MDD的可能性。另一方面,复原力起到保护机制的作用,降低应激反应性并支持心理健康。主要研究结果表明,健康的生活方式习惯,包括规律的睡眠模式、均衡的饮食和定期锻炼,在增强复原力和预防抑郁症状方面发挥着重要作用。培养复原力的干预措施,如情绪技能训练和培养成长型思维模式,已被证明在减轻抑郁症状方面有效。总体而言,研究结果表明,生活方式的改变与增强复原力的心理策略相结合,可以显著减少抑郁症。本研究提倡采用个性化治疗策略,考虑到抑郁症的多因素性质,整合心理和生活方式干预措施以增强复原力和心理健康。