Tian Huijun, Cheng Yanwei, Qin Lijie, Zhang Peirong, Li Yun, Liang Bingwei
Department of Emergency Medicine, People's Hospital of Henan Province, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou City, 450003, Henan Province, China.
BMC Public Health. 2025 May 7;25(1):1679. doi: 10.1186/s12889-025-22887-x.
The role of noise pollution in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the correlation between nighttime sleep noise levels and the risk of acute exacerbations of this lung disease.
A total of 518 stable COPD patients were enrolled in the study. A portable sound level meter was used to measure the nighttime sleep noise levels. Subsequently, based on a threshold of 40 dB, the patients were divided into a high-noise group (n = 210) and a low-noise group (n = 308). The Pittsburgh Sleep Quality Index was employed to assess the sleep quality of the patients. During the 12-month follow-up, the events of acute exacerbation (i.e., Escalated therapy, Urgent hospitalization, and Admitted to intensive care unit) in these COPD patients were recorded. Multivariate logistic regression was utilized for data analysis.
When most potential confounding factors (i.e., demographic variable, chronic disease, risk factor of COPD, status of COPD, and inflammatory indicator) were adjusted, a higher nighttime sleep noise level was found to be associated with acute exacerbations of COPD during the follow-up period. After adjusting the sleep quality score, although the P-value of the above-mentioned correlation was still statistically significant, its level increased significantly, that is, the level of the P-value became closer to the threshold at which it would not be statistically significant.
There is a significant correlation between relatively high nighttime sleep noise level and acute exacerbations of COPD. Sleep disorders might potentially contribute in some way to the above-mentioned correlation. The exact role of nighttime sleep noise in acute exacerbations of this lung disease and the underlying mechanisms still need further research.
噪声污染在慢性阻塞性肺疾病（COPD）中的作用仍不明确。本研究旨在调查夜间睡眠噪声水平与该肺部疾病急性加重风险之间的相关性。
共有518例稳定期COPD患者纳入本研究。使用便携式声级计测量夜间睡眠噪声水平。随后，根据40分贝的阈值，将患者分为高噪声组（n = 210）和低噪声组（n = 308）。采用匹兹堡睡眠质量指数评估患者的睡眠质量。在12个月的随访期间，记录这些COPD患者的急性加重事件（即强化治疗、紧急住院和入住重症监护病房）。采用多因素逻辑回归进行数据分析。
当调整了大多数潜在混杂因素（即人口统计学变量、慢性病、COPD危险因素、COPD状态和炎症指标）后，发现较高的夜间睡眠噪声水平与随访期间COPD的急性加重相关。调整睡眠质量评分后，上述相关性的P值虽仍具有统计学意义，但其水平显著升高，即P值水平更接近无统计学意义的阈值。
较高的夜间睡眠噪声水平与COPD急性加重之间存在显著相关性。睡眠障碍可能在某种程度上导致了上述相关性。夜间睡眠噪声在该肺部疾病急性加重中的具体作用及潜在机制仍需进一步研究。
