Plant-induced resistance plays a crucial role in the plant defense system by activating intrinsic immune mechanisms. In this study, a novel amidase- and redox-responsive codelivery nanosystem was developed by covalently linking salicylic acid (SA) to functionalized disulfide-doped mesoporous silica nanoparticles (MSNs-ss-NH) for the efficient delivery of SA and bioavailable silicon concurrently. Physicochemical characterization confirmed the successful preparation of MSNs-ss-SA, demonstrating its structural integrity and glutathione and amidase responsive degradation mechanism. With a particle size of approximately 90 nm, MSNs-ss-SA could penetrate the stomata of rice leaves, facilitating the efficient intracellular transport of SA and bioavailable silicon. Biological activity assays revealed that MSNs-ss-SA exhibited superior efficacy in inducing resistance to rice sheath blight compared to conventional SA, which was primarily due to its ability to enhance physical barrier formation, strengthen antioxidant defense systems, upregulate the expression of key defense-related genes, and increase chitinase synthesis, collectively triggering both systemic acquired resistance and induced systemic resistance. Most importantly, biological safety assessments confirmed its excellent compatibility with rice plants, aquatic organisms, soil ecosystems, and human cell models. Therefore, the prodrug system of SA and bioavailable silicon shows a significant potential for sustainable agricultural plant disease management.