Kaminishi M
Nihon Geka Gakkai Zasshi. 1985 Jun;86(6):686-96.
There has not come to any definite conclusion on morphological changes in post-vagotomy gastric mucosa. And, it was reported that duodenogastric reflux in consequence of pyloroplasty or gastroenterostomy could aggravate these gastric mucosal changes. To elucidate this problem, 34 Wistar male rats were subjected to either truncal vagotomy, duodenogastric reflux procedure (transection of the lower part of the duodenum and gastrojejunostomy), or truncal vagotomy with duodenogastric reflux procedure. After 12 weeks, rats were killed for histologic studies of gastric mucosa. Rats subjected to vagotomy with duodenogastric reflux procedure showed marked atrophy of gastric glands, reduction in number of parietal cells and gastrin cells, formation of small ulcer, and generation of heterotopic glands. Rats subjected to duodenogastric reflux also showed chronic ulceration in the prepyloric region on the lesser curvature and hyperplasia of gastric glands. However, no remarkable changes were observed in the stomach of rats with vagotomy. These results indicate that chronic influence of postvagotomy duodenogastric reflux can lead to severe gastritis as well as altered structure of gastric mucosa.
关于迷走神经切断术后胃黏膜的形态学变化，尚未得出任何明确的结论。而且，据报道，幽门成形术或胃肠吻合术导致的十二指肠-胃反流会加重这些胃黏膜变化。为了阐明这个问题，对34只雄性Wistar大鼠进行了以下手术：迷走神经干切断术、十二指肠-胃反流手术（十二指肠下部横断并胃空肠吻合术）或迷走神经干切断术加十二指肠-胃反流手术。12周后，处死大鼠以进行胃黏膜的组织学研究。接受迷走神经切断术加十二指肠-胃反流手术的大鼠表现出胃腺明显萎缩、壁细胞和胃泌素细胞数量减少、小溃疡形成以及异位腺的产生。接受十二指肠-胃反流手术的大鼠在胃小弯幽门前区也出现慢性溃疡和胃腺增生。然而，接受迷走神经切断术的大鼠胃中未观察到明显变化。这些结果表明，迷走神经切断术后十二指肠-胃反流的长期影响可导致严重胃炎以及胃黏膜结构改变。
