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葛根素在体内的抗氧化、降血糖和降血脂作用

Antioxidant, Hypoglycemic, and Hypolipidemic Effects of Puerarin In Vivo.

作者信息

Ruan Hong, Li Wanqing, Chang Huien, Wen Manlin, Luo Shouchun, Song Fangshuai, Ye Li, Mei Jie, Zhu Xiqiang, Liu Xiaopeng, Jiang Ning

机构信息

Hubei Key Laboratory of Biologic Resources Protection and Utilization Hubei Minzu University Enshi People's Republic of China.

School of Biological Science and Technology Hubei Minzu University Enshi People's Republic of China.

出版信息

Food Sci Nutr. 2025 May 6;13(5):e70257. doi: 10.1002/fsn3.70257. eCollection 2025 May.

DOI:10.1002/fsn3.70257
PMID:40336535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12056237/
Abstract

Puerarin (PUE) exhibits various pharmacological effects. This study evaluated its antioxidant, hypoglycemic, and hypolipidemic effects in vivo using models of aging, diabetes, and hyperlipidemia. D-galactose-induced aging, streptozotocin (STZ)-induced diabetic, and high-fat diet-induced hyperlipidemic mouse models were established. To evaluate the therapeutic effects, mice were administered various doses of PUE (50, 100, and 200 mg/kg). Results showed that PUE treatment improved antioxidant enzyme activities and reduced serum and liver malondialdehyde (MDA) levels in aging mice, thereby mitigating cellular oxidative stress. In diabetic mice, fasting blood glucose (FBG) levels were observed to decrease, while hepatic hexokinase (HK) activity, pyruvate kinase (PK) activity, and insulin levels increased after 7 weeks of PUE treatment. Furthermore, PUE significantly enhanced blood lipid profiles and antioxidant enzyme properties in diabetic mice. In hyperlipidemic mice, PUE administration led to decreased levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), while increasing high-density lipoprotein cholesterol (HDL-C). These findings indicate that PUE possesses antioxidant, hypoglycemic, and hypolipidemic properties and shows potential for treating aging and related diseases like type 2 diabetes and hyperlipidemia.

摘要

葛根素（PUE）具有多种药理作用。本研究使用衰老、糖尿病和高脂血症模型在体内评估了其抗氧化、降血糖和降血脂作用。建立了D-半乳糖诱导的衰老、链脲佐菌素（STZ）诱导的糖尿病和高脂饮食诱导的高脂血症小鼠模型。为了评估治疗效果，给小鼠施用了不同剂量的PUE（50、100和200mg/kg）。结果表明，PUE治疗提高了衰老小鼠的抗氧化酶活性，降低了血清和肝脏丙二醛（MDA）水平，从而减轻了细胞氧化应激。在糖尿病小鼠中，PUE治疗7周后，空腹血糖（FBG）水平降低，而肝己糖激酶（HK）活性、丙酮酸激酶（PK）活性和胰岛素水平升高。此外，PUE显著改善了糖尿病小鼠的血脂谱和抗氧化酶特性。在高脂血症小鼠中，施用PUE导致总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平降低，同时高密度脂蛋白胆固醇（HDL-C）升高。这些发现表明，PUE具有抗氧化、降血糖和降血脂特性，在治疗衰老及2型糖尿病和高脂血症等相关疾病方面具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/69e174a15967/FSN3-13-e70257-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/66182caed508/FSN3-13-e70257-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/62c8621cdece/FSN3-13-e70257-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/5c87a6ef77a9/FSN3-13-e70257-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/c26b36b357f3/FSN3-13-e70257-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/93c0adff6b5d/FSN3-13-e70257-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/25a2aee9444a/FSN3-13-e70257-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/69e174a15967/FSN3-13-e70257-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/66182caed508/FSN3-13-e70257-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/62c8621cdece/FSN3-13-e70257-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/5c87a6ef77a9/FSN3-13-e70257-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/c26b36b357f3/FSN3-13-e70257-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/93c0adff6b5d/FSN3-13-e70257-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/25a2aee9444a/FSN3-13-e70257-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3873/12056237/69e174a15967/FSN3-13-e70257-g005.jpg

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Antioxidant, Hypoglycemic, and Hypolipidemic Effects of Puerarin In Vivo.

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本文引用的文献

[1]
Butein Increases Resistance to Oxidative Stress and Lifespan with Positive Effects on the Risk of Age-Related Diseases in .

Antioxidants (Basel). 2024-1-26

[2]
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Nutrients. 2023-8-3

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Mol Metab. 2023-7

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Food Funct. 2023-2-21

[8]
Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways.

Biomed Pharmacother. 2023-4

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Puerarin Protects against Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis.

Biol Pharm Bull. 2023-4-1

[10]
Puerarin Reduces Oxidative Damage and Photoaging Caused by UVA Radiation in Human Fibroblasts by Regulating Nrf2 and MAPK Signaling Pathways.

Nutrients. 2022-11-9

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