Kim Seona, Yoon Hyemin, Park Sang-Kyu
Department of Medical Sciences, General Graduate School, Soonchunhyang University, 22 Soonchunhyang-ro, Asan 31538, Republic of Korea.
Department of Medical Biotechnology, Soonchunhyang University, 22 Soonchunhyang-ro, Asan 31538, Republic of Korea.
Antioxidants (Basel). 2024 Jan 26;13(2):155. doi: 10.3390/antiox13020155.
Butein is a flavonoid found in many plants, including dahlia, butea, and coreopsis, and has both antioxidant and sirtuin-activating activities. In light of the postulated role of free radicals in aging, we examined the effects of butein on aging and on genetic or nutritional models of age-related diseases in . Butein showed radical scavenging activity and increased resistance to oxidative stress in . The mean lifespan of was significantly increased by butein, from 22.7 days in the untreated control to 25.0 days in the butein-treated group. However, the lifespan-extending effect of butein was accompanied by reduced production of progeny as a trade-off. Moreover, the age-related decline in motility was delayed by butein supplementation. Genetic analysis showed that the lifespan-extending effect of butein required the autophagic protein BEC-1 and the transcription factor DAF-16 to regulate stress response and aging. At the genetic level, expression of the DAF-16 downstream target genes and was induced in butein-treated worms. Butein additionally exhibited a preventive effect in models of age-related diseases. In an Alzheimer's disease model, butein treatment significantly delayed the paralysis caused by accumulation of amyloid-beta in muscle, which requires SKN-1, not DAF-16. In a high-glucose-diet model of diabetes mellitus, butein markedly improved survival, requiring both SKN-1 and DAF-16. In a Parkinson's disease model, dopaminergic neurodegeneration was completely inhibited by butein supplementation and the accumulation of α-synuclein was significantly reduced. These findings suggest the use of butein as a novel nutraceutical compound for aging and age-related diseases.
紫铆因是一种存在于许多植物中的黄酮类化合物，包括大丽花、紫铆和金鸡菊，具有抗氧化和激活沉默调节蛋白的活性。鉴于自由基在衰老过程中的假定作用，我们研究了紫铆因对衰老以及对衰老相关疾病的遗传或营养模型的影响。紫铆因在……中表现出自由基清除活性并增强了对氧化应激的抵抗力。紫铆因显著延长了……的平均寿命，从未经处理的对照组的22.7天延长至紫铆因处理组的25.0天。然而，作为一种权衡，紫铆因的寿命延长作用伴随着后代产量的减少。此外，补充紫铆因可延缓与年龄相关的运动能力下降。遗传分析表明，紫铆因的寿命延长作用需要自噬蛋白BEC-1和转录因子DAF-16来调节应激反应和衰老。在基因水平上，在紫铆因处理的蠕虫中诱导了DAF-16下游靶基因……的表达。紫铆因在衰老相关疾病模型中还表现出预防作用。在阿尔茨海默病模型中，紫铆因治疗显著延迟了由肌肉中淀粉样β蛋白积累引起的麻痹，这需要SKN-1，而不是DAF-16。在糖尿病的高糖饮食模型中，紫铆因显著提高了存活率，这需要SKN-1和DAF-16。在帕金森病模型中，补充紫铆因可完全抑制多巴胺能神经变性，并且α-突触核蛋白的积累显著减少。这些发现表明紫铆因可作为一种用于衰老和衰老相关疾病的新型营养化合物。
