Greenlund Ian M, Barnes Jill N, Baker Sarah E, Somers Virend K, Bock Joshua M
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN USA.
Bruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, WI USA.
NPJ Womens Health. 2025;3(1):27. doi: 10.1038/s44294-025-00076-w. Epub 2025 May 5.
Obstructive sleep apnea (OSA) significantly impacts cardiovascular health in post-menopausal females. Given that cardiovascular and cerebrovascular diseases are tightly linked, OSA-mediated impacts on cerebrovascular function and Alzheimer's Disease (AD) risk are also likely more manifest in females. This review will: summarize sex differences in cerebrovascular function, review the vascular hypothesis of AD, characterize sex differences in the OSA phenotype and implications for cerebrovascular control, and highlight OSA-mediated AD risk.
阻塞性睡眠呼吸暂停（OSA）对绝经后女性的心血管健康有显著影响。鉴于心血管疾病和脑血管疾病紧密相关，OSA对脑血管功能和阿尔茨海默病（AD）风险的影响在女性中可能也更为明显。本综述将：总结脑血管功能的性别差异，回顾AD的血管假说，描述OSA表型的性别差异及其对脑血管控制的影响，并强调OSA介导的AD风险。
